NOS2 and AATF

		NOS2	AATF
Description		nitric oxide synthase 2	apoptosis antagonizing transcription factor
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GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Peroxisome Peroxisomal Matrix Cytosol Plasma Membrane Vesicle Membrane Cortical Cytoskeleton Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Nuclear Transcription Factor Complex
	Molecular Function	NADPH-hemoprotein Reductase Activity Nitric-oxide Synthase Activity Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Tetrahydrobiopterin Binding Arginine Binding Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding	RNA Binding Protein Binding Protein Kinase Binding Leucine Zipper Domain Binding Tau Protein Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Leukocyte Mediated Cytotoxicity Innate Immune Response In Mucosa Arginine Catabolic Process Protein Targeting To Peroxisome Superoxide Metabolic Process Nitric Oxide Biosynthetic Process Nitric Oxide Mediated Signal Transduction Circadian Rhythm Response To Bacterium Response To Hormone Negative Regulation Of Gene Expression Peptidyl-cysteine S-nitrosylation Cytokine-mediated Signaling Pathway Positive Regulation Of Guanylate Cyclase Activity Prostaglandin Secretion Response To Lipopolysaccharide Cellular Response To Drug Regulation Of Cell Proliferation Negative Regulation Of Protein Catabolic Process Defense Response To Bacterium Regulation Of Cellular Respiration Cell Redox Homeostasis Negative Regulation Of Blood Pressure Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Positive Regulation Of Killing Of Cells Of Other Organism Oxidation-reduction Process Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Interleukin-6 Secretion Interleukin-8 Secretion Regulation Of Cytokine Production Involved In Inflammatory Response	Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Negative Regulation Of Superoxide Anion Generation Ribosome Biogenesis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		ROS and RNS production in phagocytes Nitric oxide stimulates guanylate cyclase Interleukin-4 and Interleukin-13 signaling Peroxisomal protein import Peroxisomal protein import Inhibition of nitric oxide production	NRAGE signals death through JNK
Drugs		L-Arginine L-Citrulline Miconazole Dexamethasone N,N-dimethylarginine 4r-Fluoro-N6-Ethanimidoyl-L-Lysine 3-Bromo-7-Nitroindazole N-(3-(Aminomethyl)Benzyl)Acetamidine 7-Nitroindazole S-Ethylisothiourea Thiocoumarin N-Omega-Propyl-L-Arginine 6-Nitroindazole N-Omega-Hydroxy-L-Arginine Imidazole N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine L-Thiocitrulline L-erythro-7,8-dihydrobiopterin 5-Nitroindazole KD7040 ACCLAIM Pimagedine 5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE 4-(1H-IMIDAZOL-1-YL)PHENOL 1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINE Triflusal
Diseases		Esophageal cancer
GWAS		Ankylosing spondylitis ( 23749187 30946743) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 23128233) Cutaneous psoriasis ( 26626624) Fractional exhaled nitric oxide (childhood) ( 24315451) Inflammatory skin disease ( 25574825) Psoriasis ( 25903422 20953189 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624)	Body mass index ( 26426971) Erectile dysfunction ( 30583798) Obesity-related traits ( 23251661)
Interacting Genes		12 interacting genes: AATF ACTB ACTN4 CAV1 PEX5 RAC1 RAC2 SLC9A3R1 SPSB1 SPSB2 SPSB4 SRC	33 interacting genes: ATM ATR AURKA CCL5 CCL7 CHEK1 CHEK2 CPD DAPK3 DAZAP2 EFNB3 FBXO7 HIPK2 LDOC1 LZTR1 MAPT MPHOSPH6 MPP6 MYO1D NEDD4L NGDN NOS2 NPTN PAWR PCBD2 POLR2J RB1 RELA SMAD3 SP1 SS18L1 TSG101 ZNF468
Entrez ID		4843	26574
HPRD ID		01225	12236
Ensembl ID		ENSG00000007171	ENSG00000275700
Uniprot IDs		P35228	Q9NY61
PDB IDs		1NSI 2LL6 2NSI 3E7G 3EJ8 3HR4 4CX7 4NOS 5TP6 5XN3	5W6A
Enriched GO Terms of Interacting Partners?
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