NME1 and PID1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NME1	PID1
Description		NME/NM23 nucleoside diphosphate kinase 1	phosphotyrosine interaction domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Mitochondrial Outer Membrane Centrosome Cytosol Intermediate Filament Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm
	Molecular Function	Magnesium Ion Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Single-stranded DNA Binding RNA Binding Deoxyribonuclease Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding GTP Binding Intermediate Filament Binding Enzyme Binding Identical Protein Binding Gamma-tubulin Binding Ribosomal Small Subunit Binding	Protein Binding
	Biological Process	Negative Regulation Of Myeloid Leukocyte Differentiation Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Metabolic Process Endocytosis Lactation Negative Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Amine Nucleobase-containing Small Molecule Interconversion Hippocampus Development Response To Testosterone Cellular Response To Drug Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epithelial Cell Proliferation Response To CAMP Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid	Negative Regulation Of Protein Phosphorylation Energy Reserve Metabolic Process Positive Regulation Of Gene Expression Regulation Of Mitochondrial Fusion Cellular Response To Leptin Stimulus Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Fat Cell Proliferation Mitochondrion Morphogenesis Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Fatty Acid Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of ATP Biosynthetic Process Positive Regulation Of ATP Biosynthetic Process
Pathways		Interconversion of nucleotide di- and triphosphates
Drugs		Zinc 2'-Deoxyguanosine-5'-Triphosphate Selenocysteine 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate Adenosine Phosphonoacetic Acid 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Triphosphate Thymidine-5'- Diphosphate 2'-Deoxyguanosine-5'-Diphosphate Fudp Guanosine-5'-Diphosphate 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate 3'-Azido-3'-Deoxythymidine-5'-Diphosphate Copper
Diseases
GWAS		Bipolar disorder ( 31043756) Metabolite levels ( 23823483)	Chronic obstructive pulmonary disease ( 28166215 30804561) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (antimigraine preparations) ( 31015401) Peak expiratory flow ( 30804560) Pulmonary function (smoking interaction) ( 23284291) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Total cholesterol levels ( 30498476) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432)
Interacting Genes		29 interacting genes: APEX1 AURKA CCND3 FBXO24 FXR2 GORASP2 ITGB1 KSR1 MIF NIF3L1 NME2 NME3 NME4 NTAQ1 PID1 POLR1C PRUNE1 PTEN RAC1 RORA RORB RRAD SET SMARCD1 SOX30 SREK1IP1 TERF1 TIAM1 TNPO2	13 interacting genes: ADAMTSL4 BANP CBY2 CCDC33 CRX GOLGA2 GOPC KRTAP10-1 LRP1 MDFI NME1 NOTCH2NLA THAP1
Entrez ID		4830	55022
HPRD ID		01131	07944
Ensembl ID		ENSG00000239672	ENSG00000153823
Uniprot IDs		A0A384MTW7 P15531	Q7Z2X4
PDB IDs		1JXV 1UCN 2HVD 2HVE 3L7U 4ENO 5UI4
Enriched GO Terms of Interacting Partners?
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