NGFR and CD80

Number of citations of the paper that reports this interaction (PubMedID 21982860)
16

Data Source:
BioGRID (pull down)

		NGFR	CD80
Description		nerve growth factor receptor	CD80 molecule
Image
GO Annotations	Cellular Component	Extracellular Region Cell Nucleoplasm Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Postsynaptic Density Integral Component Of Membrane Growth Cone Dendritic Spine Perikaryon	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Protein Complex Involved In Cell Adhesion
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Calmodulin Binding Coreceptor Activity Rab GTPase Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Neurotrophin Binding Nerve Growth Factor Binding	Virus Receptor Activity Protein Binding Coreceptor Activity
	Biological Process	Cellular Glucose Homeostasis Intracellular Protein Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Rho Protein Signal Transduction Axon Guidance Central Nervous System Development Detection Of Temperature Stimulus Nerve Development Hair Follicle Morphogenesis Membrane Protein Intracellular Domain Proteolysis Circadian Regulation Of Gene Expression Dorsal Aorta Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Neuron Apoptotic Process Negative Regulation Of Hair Follicle Development Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Response To Amyloid-beta Positive Regulation Of Apoptotic Signaling Pathway	Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway T Cell Costimulation Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide
Pathways		Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling Regulated proteolysis of p75NTR NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Abatacept Galiximab Belatacept Durvalumab
Diseases
GWAS		Immune reponse to smallpox (secreted IL-2) ( 22610502) Lower body strength ( 27325353) Prostate cancer ( 23535732)	Carotid plaque burden ( 28282560) Celiac disease ( 20190752) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lobular breast cancer (menopausal hormone therapy interaction) ( 24080446) Primary biliary cholangitis ( 28425483 23000144 21399635 26394269 28062665) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 23273568 25862617) Systemic sclerosis ( 31672989) Vitiligo ( 27723757 22561518)
Interacting Genes		48 interacting genes: ANXA7 BEX1 BEX3 BNIP3L CAV1 CD80 CDKN1A FSCN1 GRB2 H2AX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 MDM2 NDN NFKBIB NGF NSMCE3 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TP53 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1 ZNF274	5 interacting genes: CD274 CD28 CD86 CTLA4 NGFR
Entrez ID		4804	941
HPRD ID		01197	00202
Ensembl ID		ENSG00000064300	ENSG00000121594
Uniprot IDs		P08138	A0N0P2 P33681
PDB IDs		2N80 2N83 2N97 3EWV 5ZGG	1DR9 1I8L
Enriched GO Terms of Interacting Partners?
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