NFKB1 and RELA

Number of citations of the paper that reports this interaction (PubMedID 8428580)
55

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		NFKB1	RELA
Description		nuclear factor kappa B subunit 1	RELA proto-oncogene, NF-kB subunit
Image
GO Annotations	Cellular Component	Nuclear Chromatin Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol I-kappaB/NF-kappaB Complex Secretory Granule Lumen Specific Granule Lumen	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Cytosol I-kappaB/NF-kappaB Complex NF-kappaB P50/p65 Complex Glutamatergic Synapse
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Identical Protein Binding Actinin Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding Peptide Binding Phosphate Ion Binding Identical Protein Binding Protein Homodimerization Activity Actinin Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Protein-containing Complex Binding Protein N-terminus Binding NF-kappaB Binding Repressing Transcription Factor Binding Ankyrin Repeat Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Stimulatory C-type Lectin Receptor Signaling Pathway Transcription By RNA Polymerase II Apoptotic Process Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Negative Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Vitamin D Biosynthetic Process Membrane Protein Intracellular Domain Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cholesterol Transport Positive Regulation Of Type I Interferon Production Cellular Response To Stress Response To Cytokine Response To Muscle Stretch NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Neutrophil Degranulation Negative Regulation Of Interleukin-12 Biosynthetic Process Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To DsRNA Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Hyaluronan Biosynthetic Process Cellular Response To Angiotensin Positive Regulation Of MiRNA Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Liver Development Hair Follicle Development Stimulatory C-type Lectin Receptor Signaling Pathway Acetaldehyde Metabolic Process Chromatin Organization Regulation Of Transcription, DNA-templated Inflammatory Response Cellular Defense Response I-kappaB Kinase/NF-kappaB Signaling Aging Positive Regulation Of Cell Proliferation Animal Organ Morphogenesis Response To Organic Substance Response To UV-B Positive Regulation Of Schwann Cell Differentiation Viral Process Cytokine-mediated Signaling Pathway Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Type I Interferon Production Response To Muramyl Dipeptide Response To Progesterone Response To Insulin Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Protein Sumoylation Cellular Response To Stress Response To Cobalamin Response To Cytokine Cellular Response To Hepatocyte Growth Factor Stimulus Cellular Response To Vascular Endothelial Growth Factor Stimulus Response To Muscle Stretch NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Response To Morphine Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Interleukin-12 Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-8 Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Inflammatory Response T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Response To CAMP Defense Response To Virus Pri-miRNA Transcription By RNA Polymerase II Cellular Response To Hydrogen Peroxide Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Nicotine Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Postsynapse To Nucleus Signaling Pathway Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Cellular Response To Angiotensin Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines Transcriptional regulation of white adipocyte differentiation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway MAP3K8 (TPL2)-dependent MAPK1/3 activation Neutrophil degranulation The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation HCMV Early Events Purinergic signaling in leishmaniasis infection	Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines Transcriptional regulation of white adipocyte differentiation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection
Drugs		Acetylsalicylic acid Thalidomide Pranlukast HE3286 P54 NOX-700 SGN-30 Custirsen Andrographolide Triflusal	Dimethyl fumarate
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Copper levels ( 26025379) Creatinine levels ( 29124443) Crohn's disease ( 28067908) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Estimated glomerular filtration rate ( 29124443 30604766) Glomerular filtration rate (creatinine) ( 26831199) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Inflammatory bowel disease ( 28067908) Lymphocyte percentage of white cells ( 27863252) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 21833088) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483 23000144 21399635 26394269 28062665 30643196) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 27992413) Schizophrenia (treatment resistant) ( 22479419) Serum total protein level ( 29403010) Serum uric acid levels ( 29124443) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 31672989 30247649) Tonsillectomy ( 27182965 28928442) Ulcerative colitis ( 23128233)	Acne (severe) ( 24927181) Asthma ( 31619474) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Inflammatory bowel disease ( 23128233) Sensation seeking ( 30718321) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Urate levels ( 31578528)
Interacting Genes		104 interacting genes: ABCC2 APBB2 AR ATF3 BCL3 BRCA1 BTRC CDK9 CEBPB CFLAR CHUK COPB2 COPS5 CTNNB1 DNMT3L E2F1 ECSIT ELF1 ELF3 ESR1 ETS1 FBXW11 FOS G3BP2 GLUL GSK3B HDAC1 HMGA1 HMGA2 HMGB1 HSPA4 IKBKB IKBKG IL2RA IRF1 IRF2 IRF8 IRF9 ITGB3BP KAT5 KLF5 KPNA3 LYL1 MAP3K8 MEN1 MPP6 MTPN NCOA1 NCOA6 NCOR2 NFKB2 NFKBIA NFKBIB NFKBIE NFKBIZ NFRKB NKRF NOTCH1 NR3C1 NR4A1 PARP1 PCBD1 PDCD11 PELP1 PLD3 PML PPARG PPP4C PRKACA PSMD10 REL RELA RELB RGS14 RIPK1 RPS3 RSF1 RXRA SERPINA3 SF1 SIN3A SP1 SPAG9 SPI1 SPPL2A SRF STAT3 STAT6 TAB2 TFAP2A TNFSF11 TNIP1 TNIP2 TP53BP1 TP53BP2 TRIP4 TSC22D3 TXN UBE2D3 UBE2K UNC5CL YWHAQ YY1 ZBTB9	195 interacting genes: AATF ACTL6A AGO1 AHR AKAP8 APBA2 AR ARNT AURKA BATF2 BRCA1 BRMS1 BTK BTRC C1QB CALM1 CAMK4 CARM1 CCL5 CCND2 CDC34 CDK9 CEBPB CEBPD CHEK1 CHUK CNNM3 COL2A1 COMMD1 CREBBP CSNK1G1 CSNK2A1 CSNK2A2 DDC DDX1 DHX9 DNAJA3 DNMT3L ECSIT EEF1D EGR1 EP300 EPHA2 ESR1 ETHE1 EZH2 FAF1 FKBP11 FOS FUS GLIS1 GOPC GTF2B HDAC1 HDAC2 HDAC3 HEXIM1 HMGA2 HMGB1 HSPA4 IGF1R IKBKB IKBKE IKBKG ING4 IRAK1BP1 IRF1 IRF2 IRF3 IRF8 IRF9 ISL1 JUN KAT2A KAT2B KAT5 KDM2A KEAP1 KPNA2 LATS2 LMO2 MAP2K6 MAP3K7 MAP3K8 MAPK10 MAPK14 MED15 MED23 MED7 MEN1 MKRN2 MST1R MTPN MX1 MYC NCOA3 NCOA6 NCOR2 NFIC NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NKRF NKX2-1 NOTCH1 NPM1 NR3C1 PARP1 PDCD11 PGR PIAS1 PIAS3 PIK3CA PIN1 PKM PLA2G4A PLK1 PML POU2F1 PPARA PPARG PPP1R13L PPP2CA PPP2CB PPP2R1B PPP4C PRKACA PRKCZ PRMT1 PRTN3 PSMD10 RAD51 RASSF1 REL RELB REPS2 RFC1 RIOK2 RNASE1 RNF25 RPL13 RPL23 RPS3 RPS6KA5 RXRA SAT1 SETD7 SIN3A SIRT1 SMAD3 SMAD4 SNIP1 SNRNP70 SOCS1 SOCS6 SORD SP1 SRF STAT1 STAT3 STAT6 TAF1 TAF11 TAF4B TAF6 TAF9 TBK1 TBP TCAP TCF4 TERT TGM2 TLE5 TNIP2 TP53 TP53BP1 TP53BP2 TRIB3 TRIP4 TSC22D3 TWIST1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBE2L3 UNC5CL USF2 USP7 ZBTB7A ZBTB7B
Entrez ID		4790	5970
HPRD ID		01238	01241
Ensembl ID		ENSG00000109320	ENSG00000173039
Uniprot IDs		P19838	A0A087X0W8 Q04206
PDB IDs		1MDI 1MDJ 1MDK 1NFI 1SVC 2DBF 2O61 3GUT	1NFI 2LSP 2O61 3GUT 3QXY 3RC0 4KV1 4KV4 5U4K 5URN
Enriched GO Terms of Interacting Partners?
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