NFATC4 and JUP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		NFATC4	JUP
Description		nuclear factor of activated T cells 4	junction plakoglobin
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex Cytosol Nuclear Speck Nuclear Transcription Factor Complex	Cornified Envelope Extracellular Region Cell Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Actin Cytoskeleton Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Peroxisome Proliferator Activated Receptor Binding	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Protein-containing Complex Binding Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Cytokine Production Transcription By RNA Polymerase II Inflammatory Response Heart Development Long-term Memory Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Wnt Signaling Pathway Brain-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Tumor Necrosis Factor Production Calcineurin-NFAT Signaling Cascade Cellular Response To UV Negative Regulation Of Chromatin Binding Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Dendrite Morphogenesis Smooth Muscle Cell Differentiation Muscle Cell Development Long-term Synaptic Potentiation Cellular Response To Lithium Ion Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Cellular Response To Ionomycin Negative Regulation Of Synapse Maturation Positive Regulation Of Apoptotic Signaling Pathway	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cytoskeletal Anchoring At Plasma Membrane Cell Migration Keratinization Adherens Junction Organization Regulation Of Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Neutrophil Degranulation Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Positive Regulation Of DNA-binding Transcription Factor Activity Cornification Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways			Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs			Zinc
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome
GWAS		Diastolic blood pressure ( 27841878) Height ( 20881960 25282103 23563607)	Heel bone mineral density ( 30598549 28869591)
Interacting Genes		12 interacting genes: CCNG1 CREBBP GATA4 GPR22 JUP MAPK14 MAPK8 MAPK9 NLGN3 NR1I2 YWHAQ YWHAZ	47 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CCDC130 CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNBIP1 CTNND1 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 FER FHL2 FYN MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 SRC TBP TCF4 TCF7L2 ZFYVE9
Entrez ID		4776	3728
HPRD ID		09096	01414
Ensembl ID		ENSG00000100968	ENSG00000173801
Uniprot IDs		Q14934	A0A0S2Z487 P14923
PDB IDs		2YRP	3IFQ
Enriched GO Terms of Interacting Partners?
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