ATP1A1 and FXYD1

Number of citations of the paper that reports this interaction (PubMedID 14597563)
38

Data Source:
HPRD (in vivo)

		ATP1A1	FXYD1
Description		ATPase Na+/K+ transporting subunit alpha 1	FXYD domain containing ion transport regulator 1
Image		No pdb structure
GO Annotations	Cellular Component	Cell Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Postsynaptic Density Intercalated Disc Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Organelle Membrane Protein-containing Complex Sperm Flagellum Sarcolemma Melanosome Membrane Raft Photoreceptor Inner Segment Membrane Extracellular Exosome Extracellular Vesicle	Plasma Membrane Integral Component Of Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Apical Plasma Membrane T-tubule Sarcolemma
	Molecular Function	Sodium:potassium-exchanging ATPase Activity Protein Binding ATP Binding Phosphatase Activity Protein Kinase Binding Protein Domain Specific Binding Ankyrin Binding Potassium Ion Binding Sodium Ion Binding ADP Binding Phosphatidylinositol 3-kinase Binding Protein Heterodimerization Activity Chaperone Binding Steroid Hormone Binding	Chloride Channel Activity Sodium Channel Regulator Activity Ion Channel Binding Ion Channel Regulator Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Regulation Of Sodium Ion Transport Cellular Sodium Ion Homeostasis Regulation Of Blood Pressure Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Dephosphorylation Cellular Potassium Ion Homeostasis Negative Regulation Of Glucocorticoid Biosynthetic Process Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Response To Drug Negative Regulation Of Heart Contraction Positive Regulation Of Heart Contraction Positive Regulation Of Striated Muscle Contraction Relaxation Of Cardiac Muscle Membrane Hyperpolarization Cellular Response To Mechanical Stimulus Cellular Response To Steroid Hormone Stimulus Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane	Potassium Ion Transport Sodium Ion Transport Chloride Transport Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Protein Glutathionylation Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Chloride Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Regulation Of Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Ion homeostasis Ion transport by P-type ATPases	Ion homeostasis Ion transport by P-type ATPases
Drugs		Digoxin Acetyldigitoxin Hydroflumethiazide Etacrynic acid Trichlormethiazide Deslanoside Ouabain Diazoxide Bretylium Ciclopirox Bepridil Potassium Aluminium Magnesium Digitoxin Almitrine
Diseases
GWAS		Coffee consumption ( 29367735) Macular thickness ( 30535121)
Interacting Genes		16 interacting genes: A2M ADD1 CFL1 EGFR EZH2 FXYD1 FXYD2 FXYD7 HGS MAPK1 MAPK3 NDRG1 PRKCA TPT1 ZNRF1 ZNRF2	8 interacting genes: ATP1A1 ATP1B1 DMPK PAM PLPP1 PPP1CA PRKACA YWHAQ
Entrez ID		476	5348
HPRD ID		01662	03837
Ensembl ID		ENSG00000163399	ENSG00000266964
Uniprot IDs		P05023	O00168
PDB IDs			2J1I 2JO1
Enriched GO Terms of Interacting Partners?
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