NEU2 and NOTCH2NLA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		NEU2	NOTCH2NLA
Description		neuraminidase 2	notch 2 N-terminal like A
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Cytosol Membrane Intracellular Membrane-bounded Organelle Catalytic Complex	Extracellular Region Cytoplasm
	Molecular Function	Exo-alpha-sialidase Activity Protein Binding Exo-alpha-(2->3)-sialidase Activity Exo-alpha-(2->6)-sialidase Activity Exo-alpha-(2->8)-sialidase Activity	Notch Binding Calcium Ion Binding Protein Binding
	Biological Process	Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Oligosaccharide Catabolic Process Cellular Oligosaccharide Catabolic Process	Notch Signaling Pathway Cerebral Cortex Development Cell Differentiation Positive Regulation Of Notch Signaling Pathway
Pathways		Glycosphingolipid metabolism Sialic acid metabolism
Drugs		Oseltamivir Zanamivir 2-Deoxy-2,3-Dehydro-N-Acetyl-Neuraminic Acid 5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-6-ISOBUTOXY-4H-PYRAN-2-CARBOXYLIC ACID
Diseases
GWAS		Contrast sensitivity ( 24152035) Metabolic syndrome ( 31589552)
Interacting Genes		1 interacting genes: NOTCH2NLA	242 interacting genes: ACY3 ADAMTSL3 ADAMTSL5 ADCK5 ALDH3B1 ALPI AQP1 AQP5 ARID3A ASPSCR1 ATG9A BCL6B BLCAP BMP7 C11orf87 C5orf60 CA6 CARHSP1 CATSPER1 CCDC26 CCDC93 CCER1 CD164 CDK5R1 CERK CHCHD3 CHDH CHIC2 CHRD CHRNG CLDN2 CLEC18A COL8A1 CRACR2A CRCT1 CREB5 CSF1 CST2 CST9L CTSG CTSZ CXCL16 CXCL5 DGCR6 DHRS1 DMRT3 DNAL4 DOCK2 EFNA3 EIF4E2 ELANE EPHB6 ESR2 FAAH FAM124B FAM71C FAM71E2 FAM74A4 FARS2 FASLG FBXL18 FBXW5 FOXB1 FRS3 GABRD GATA2 GEM GFOD1 GIP GLP1R GLRX3 GLYAT GNAI2 GNE GNMT GSTP1 GTF3C5 H2AC15 HBZ HCK HOXA1 HPCAL1 HSBP1 HSD3B7 HSPA12B HSPBP1 HSPD1 ICAM4 IFI30 IL2RG INPP5D ITGB2 ITGB5 JOSD1 KCTD15 KIF1A KLHL38 KLK8 KRT20 KRT83 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-4 KRTAP13-3 KRTAP26-1 KRTAP3-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LIMS2 LIN7A LINC00526 LINC00656 LMO2 LNX1 LONRF3 LRCH4 LRFN4 MAPKBP1 MARK4 MATN3 MELTF MRGBP MRPL40 MTA1 MVP MXD3 MXI1 NAB2 NAXD NECTIN2 NECTIN3 NEU2 NMU NMUR2 NPBWR2 NPDC1 NPPB NR1D2 NUBP2 P2RX4 PCED1A PCED1B PCSK5 PDE9A PGLS PID1 PIGS PLPP2 PLSCR4 POLR2G POM121L8P POMGNT2 PRKAA2 PRPF31 PRPS2 PSMA1 PSMG2 PTGER3 PTPMT1 PTPN23 PVR QPRT R3HDM2 RAB3IL1 RAMP3 RCHY1 RECK RET RGL2 RPS28 RTN4RL1 SCNM1 SDCBP SELENOM SEMA4C SHFL SLC22A23 SLC23A1 SLC25A10 SLC25A6 SLC6A20 SMARCD2 SMARCE1 SMCP SMOC1 SNAI1 SPATA8 SPG7 SPINK2 SPRY1 STK16 TBC1D10C TBC1D16 TEDC2 THAP7 THEMIS2 TINAGL1 TLE5 TMEM150A TMEM231 TMEM41A TNIP3 TNK2 TNP2 TRIM27 TRIM42 TRPV6 TSPAN4 TXNDC5 UBQLN4 UTP23 UXT WDR25 WT1-AS XCL2 YIPF3 ZFYVE21 ZNF124 ZNF32 ZNF417 ZNF439 ZNF440 ZNF446 ZNF581 ZNF587 ZNF688
Entrez ID		4759	388677
HPRD ID		05702	14833
Ensembl ID		ENSG00000115488	ENSG00000264343
Uniprot IDs		Q9Y3R4	P0DPK4 Q7Z3S9
PDB IDs		1SNT 1SO7 1VCU 2F0Z 2F10 2F11 2F12 2F13 2F24 2F25 2F26 2F27 2F28 2F29 4NC5 4NCS
Enriched GO Terms of Interacting Partners?
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