NEFM and TNIK

Number of citations of the paper that reports this interaction (PubMedID 17043677)
168

Data Source:
BioGRID (two hybrid)

		NEFM	TNIK
Description		neurofilament medium	TRAF2 and NCK interacting kinase
Image		No pdb structure
GO Annotations	Cellular Component	Neurofilament Axon Intermediate Filament Cytoskeleton Neurofibrillary Tangle	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Exosome Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Neurofilament Bundle Assembly	Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cytoskeleton Organization Activation Of JNKK Activity Regulation Of Mitotic Cell Cycle Wnt Signaling Pathway Signal Transduction By Protein Phosphorylation Microvillus Assembly Stress-activated Protein Kinase Signaling Cascade Actin Cytoskeleton Reorganization Activation Of Protein Kinase Activity Intracellular Signal Transduction Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane
Pathways			Oxidative Stress Induced Senescence
Drugs
Diseases
GWAS		Fear of minor pain ( 28701861) Idiopathic dilated cardiomyopathy ( 29495422) Interleukin-6 levels ( 22205395) Metabolite levels ( 23823483)	Adolescent idiopathic scoliosis ( 28334814) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Cerebrospinal fluid AB1-42 levels ( 29274321) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Frontotemporal dementia (age at onset) ( 29724592) Hip circumference adjusted for BMI ( 28552196) LDL cholesterol ( 21347282) Lymphocyte counts ( 27863252) Night sleep phenotypes ( 27126917) Response to antipsychotic treatment in schizophrenia ( 29503163) Type 2 diabetes ( 30054458)
Interacting Genes		10 interacting genes: APOE DISC1 DRD2 FOS MINK1 NEFH RB1 SMAD2 STXBP1 TNIK	37 interacting genes: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS1 MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SMARCE1 SMURF1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1
Entrez ID		4741	23043
HPRD ID		01205	18206
Ensembl ID		ENSG00000104722	ENSG00000154310
Uniprot IDs		P07197 Q9UK51	Q9UKE5
PDB IDs			2X7F 5AX9 5CWZ 5D7A 6RA7
Enriched GO Terms of Interacting Partners?
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