NDUFV2 and SP110

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NDUFV2	SP110
Description		NADH:ubiquinone oxidoreductase core subunit V2	SP110 nuclear body protein
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I	Nucleus Nucleoplasm
	Molecular Function	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Metal Ion Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Nervous System Development Respiratory Electron Transport Chain Mitochondrial Respiratory Chain Complex I Assembly Cardiac Muscle Tissue Development	Regulation Of Transcription By RNA Polymerase II Viral Process
Pathways		Respiratory electron transport Complex I biogenesis
Drugs		NADH
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Waist circumference adjusted for body mass index ( 28552196)	B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Chronic lymphocytic leukemia ( 18758461 28165464 24292274) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Subcutaneous adipose tissue ( 26480920)
Interacting Genes		3 interacting genes: CRMP1 KAT5 SP110	11 interacting genes: ANXA7 CDKN1A NAP1L2 NDUFV2 OSGEP RUNX3 SMN1 TK1 TSC22D1 TTR ZSCAN9
Entrez ID		4729	3431
HPRD ID		02757	06832
Ensembl ID		ENSG00000178127	ENSG00000135899
Uniprot IDs		P19404	Q9HB58
PDB IDs		5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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