NCF2 and S100A9

Number of citations of the paper that reports this interaction (PubMedID 15642721)
46

Data Source:
BioGRID (pull down)

		NCF2	S100A9
Description		neutrophil cytosolic factor 2	S100 calcium binding protein A9
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Cell Nucleolus Cytosol Membrane Phagolysosome NADPH Oxidase Complex	Extracellular Region Extracellular Space Cell Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Junction Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Electron Transfer Activity Superoxide-generating NADPH Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity Rac GTPase Binding	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Antioxidant Activity Toll-like Receptor 4 Binding Arachidonic Acid Binding RAGE Receptor Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Phagocytosis Cellular Defense Response Electron Transport Chain Cellular Response To Oxidative Stress Superoxide Anion Generation Positive Regulation Of Catalytic Activity Innate Immune Response Cell Redox Homeostasis Respiratory Burst Vascular Endothelial Growth Factor Receptor Signaling Pathway Oxidation-reduction Process	Cytokine Production Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Autophagy Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Cell-cell Signaling Positive Regulation Of Neuron Projection Development Antimicrobial Humoral Response Positive Regulation Of Cell Growth Neutrophil Chemotaxis Sequestering Of Zinc Ion Chemokine Production Peptidyl-cysteine S-trans-nitrosylation Modification Of Morphology Or Physiology Of Other Organism Defense Response To Bacterium Neutrophil Degranulation Innate Immune Response Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytoskeleton Organization Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Neutrophil Aggregation Cellular Oxidant Detoxification Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases	RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins
Drugs		Dextromethorphan	Calcium Zinc
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Celiac disease and Rheumatoid arthritis ( 26546613) Systemic lupus erythematosus ( 27399966 26606652 26502338 28714469 19838195) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)	Asthma ( 31619474) Matrix metalloproteinase-8 levels ( 29212897)
Interacting Genes		14 interacting genes: AKT1 CDC42 CYBA CYBB GOLGA2 KIFAP3 NCF4 PRDX6 PRKDC RAC1 RAC2 S100A8 S100A9 SYTL1	9 interacting genes: CDC42 EGFR MAPK14 NCF2 PTEN S100A8 TUBA1A TUBB USP13
Entrez ID		4688	6280
HPRD ID		01991	00472
Ensembl ID		ENSG00000116701	ENSG00000163220
Uniprot IDs		A0A0S2Z457 P19878	P06702
PDB IDs		1E96 1HH8 1K4U 1OEY 1WM5 2DMO	1IRJ 1XK4 4GGF 4XJK 5I8N 5W1F 6DS2
Enriched GO Terms of Interacting Partners?
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