NBN and TREX1

Number of citations of the paper that reports this interaction (PubMedID 15758953)
446

Data Source:
HPRD (in vivo)

		NBN	TREX1
Description		nibrin	three prime repair exonuclease 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Nucleolus Cytosol PML Body Mre11 Complex Site Of Double-strand Break Nuclear Inclusion Body	Nuclear Envelope Endoplasmic Reticulum Membrane Cytosol Oligosaccharyltransferase Complex Protein-DNA Complex Nuclear Replication Fork
	Molecular Function	DNA Helicase Activity Damaged DNA Binding Protein Binding Transcription Factor Binding Protein N-terminus Binding	Magnesium Ion Binding Double-stranded DNA Binding Single-stranded DNA Binding 3'-5'-exodeoxyribonuclease Activity DNA Binding, Bending 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity MutLalpha Complex Binding MutSalpha Complex Binding Adenyl Deoxyribonucleotide Binding Protein Homodimerization Activity Metal Ion Binding WW Domain Binding
	Biological Process	DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Blastocyst Growth DNA Replication Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Mitotic G2 DNA Damage Checkpoint Cell Proliferation Viral Process Telomere Capping Regulation Of DNA-dependent DNA Replication Initiation DNA Damage Response, Signal Transduction By P53 Class Mediator Telomeric 3' Overhang Formation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Telomere Maintenance DNA Duplex Unwinding Positive Regulation Of Kinase Activity Signal Transduction In Response To DNA Damage Isotype Switching Neuromuscular Process Controlling Balance Meiotic Cell Cycle T-circle Formation Telomere Maintenance Via Telomere Trimming Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Telomere Capping	Blood Vessel Development Kidney Development Activation Of Immune Response Macrophage Activation Involved In Immune Response Lymphoid Progenitor Cell Differentiation Immunoglobulin Biosynthetic Process Involved In Immune Response Immune Response In Brain Or Nervous System Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Regulation Of Immunoglobulin Production Heart Morphogenesis Heart Process Atrial Cardiac Muscle Tissue Development Generation Of Precursor Metabolites And Energy Regulation Of Glycolytic Process DNA Metabolic Process DNA Replication DNA Repair Mismatch Repair DNA Modification DNA Catabolic Process DNA Recombination Determination Of Adult Lifespan Regulation Of Gene Expression Regulation Of Fatty Acid Metabolic Process Transposition, RNA-mediated Regulation Of Type I Interferon Production DNA Duplex Unwinding Interferon-alpha Production Regulation Of Tumor Necrosis Factor Production Cellular Response To Reactive Oxygen Species Cellular Response To Interferon-beta CD86 Biosynthetic Process Apoptotic Cell Clearance Regulation Of Cellular Respiration Establishment Of Protein Localization Regulation Of Lipid Biosynthetic Process Regulation Of Inflammatory Response Regulation Of Catalytic Activity Protein Stabilization Regulation Of T Cell Activation Defense Response To Virus Type I Interferon Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Protein Complex Stability Cellular Response To Gamma Radiation Detection Of Stimulus Involved In Cell Cycle Checkpoint Detection Of DNA Damage Stimulus Involved In DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Cellular Response To Hydroxyurea Nucleic Acid Phosphodiester Bond Hydrolysis Immune Complex Formation DNA Synthesis Involved In UV-damage Excision Repair Regulation Of Lysosome Organization
Pathways		DNA Damage/Telomere Stress Induced Senescence HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination	Regulation by TREX1 IRF3-mediated induction of type I IFN
Drugs
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome	Familial chilblain lupus (FCL); Chilblain lupus erythematosus (CHLE) Aicardi-Goutieres Syndrome (AGS) Retinal vasculopathy with cerebral leukodystrophy (RVCL)
GWAS			Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Obesity-related traits ( 23251661) Ulcerative colitis ( 28067908)
Interacting Genes		35 interacting genes: ATF2 ATM ATR BAP1 BRCA1 CASC3 CCNE1 CDK9 CHEK2 DCLRE1C EP300 FANCD2 H2AX H3-4 HIF1A MDC1 MRE11 NAT2 NCL PRKDC RAD18 RAD50 RAD51 RECQL5 SIRT1 SNAI1 SUMO2 TERF1 TLK1 TREX1 UBE2D1 UBE2N VRK1 XRCC4 XRCC5	14 interacting genes: ATM ATR CHCHD2 IFT20 KRTAP10-7 MCM7 MSH2 NBN PRKDC RIBC2 RPA1 SET UBQLN1 VKORC1
Entrez ID		4683	11277
HPRD ID		04050	09423
Ensembl ID		ENSG00000104320	ENSG00000213689
Uniprot IDs		A0A0C4DG07 O60934	Q5TZT0 Q9NSU2
PDB IDs		5WQD
Enriched GO Terms of Interacting Partners?
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