MYO6 and TOM1L2

Number of citations of the paper that reports this interaction (PubMedID 23023224)
100

Data Source:
BioGRID (proximity labelling technology, affinity chromatography technology, two hybrid)

		MYO6	TOM1L2
Description		myosin VI	target of myb1 like 2 membrane trafficking protein
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Actin Filament Plasma Membrane Microvillus Clathrin-coated Pit Cell Cortex Actin Cytoskeleton Membrane Unconventional Myosin Complex RNA Polymerase II, Holoenzyme Endocytic Vesicle Filopodium Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Nuclear Membrane Vesicle Ruffle Membrane Cell Projection Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Exosome
	Molecular Function	Microfilament Motor Activity Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Actin-dependent ATPase Activity ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity	Protein Binding Protein Kinase Binding Clathrin Binding
	Biological Process	Intracellular Protein Transport Endocytosis Actin Filament Organization Sensory Perception Of Sound Actin Filament-based Movement Vesicle Transport Along Actin Filament DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Response To Drug Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Secretion	Intracellular Protein Transport Signal Transduction Negative Regulation Of Mitotic Nuclear Division
Pathways		Gap junction degradation Trafficking of AMPA receptors
Drugs
Diseases		Deafness, autosomal dominant Deafness, autosomal recessive
GWAS		Prostate cancer ( 25217961) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Schizophrenia ( 28991256 25056061 29483656) TB-LM or TBLH-BMD (pleiotropy) ( 28743860) Total body bone mineral density ( 29304378)
Interacting Genes		19 interacting genes: ACTA1 APC CALCOCO2 CALM2 CDC42 CDH1 DAB1 DAB2 DLG1 GIPC1 LRCH3 OPTN PAK1 PAK3 RNF11 TOM1 TOM1L2 UBC WBP2	9 interacting genes: APP LAPTM5 MAP3K1 MYO6 NEDD4 RNF11 SMURF1 UBC WBP2
Entrez ID		4646	146691
HPRD ID		02985	18213
Ensembl ID		ENSG00000196586	ENSG00000175662
Uniprot IDs		Q9UM54	B7Z2U2 B7Z671 F5H3S6 Q6ZVM7
PDB IDs		2N0Z 2N10 2N11 2N12 2N13 6E5N 6J56
Enriched GO Terms of Interacting Partners?
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