MAP3K11 and KIF3A

Number of citations of the paper that reports this interaction (PubMedID 9427749)
63

Data Source:
HPRD (two hybrid, in vivo)

		MAP3K11	KIF3A
Description		mitogen-activated protein kinase kinase kinase 11	kinesin family member 3A
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Microtubule Membrane	Cell Centrosome Centriole Cytosol Kinesin Complex Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Kinesin II Complex Extracellular Exosome Ciliary Tip Axon Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity Rac GTPase Binding	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity Rab GTPase Binding Protein Phosphatase Binding Spectrin Binding
	Biological Process	Activation Of MAPK Activity Protein Phosphorylation Microtubule-based Process JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cell Cycle G1/S Phase Transition Positive Regulation Of JNK Cascade Protein Autophosphorylation	Retrograde Vesicle-mediated Transport, Golgi To ER Organelle Organization Microtubule-based Movement Axon Guidance Anterograde Axonal Transport Centriole-centriole Cohesion Protein Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Microtubule Anchoring At Centrosome Intraciliary Transport Involved In Cilium Assembly Cilium Assembly Plus-end-directed Vesicle Transport Along Microtubule Protein Localization To Cell Junction
Pathways		RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Hedgehog 'off' state Intraflagellar transport Activation of SMO Activation of SMO COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
Drugs
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Eosinophil counts ( 27863252) Estimated glomerular filtration rate ( 31015462) Gout ( 25646370) Mean platelet volume ( 27863252) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 28566273 30297969)	Asthma ( 31619474) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 25574825 22197932 26482879) Atopic march ( 26542096) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695)
Interacting Genes		27 interacting genes: AKT1 APP CDC42 CHUK CLEC4G COPS5 EPS8 IKBKB KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP2K7 MAP3K12 MAP3K21 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 PIN1 RAC1 RHOG SH3RF1 STUB1 TRAF6	14 interacting genes: APP DISC1 GRB2 KIF3B KIF3C LIG4 MAP3K10 MAP3K11 NEK1 PLEKHA5 PPP1R15A RPGR TRIM14 VHL
Entrez ID		4296	11127
HPRD ID		02502	05250
Ensembl ID		ENSG00000173327	ENSG00000131437
Uniprot IDs		A0A024R5E6 Q16584	B4DHG8 E9PES4 J3KPF9 Q05CT3 Q9Y496
PDB IDs		5K26 5K28 6AQB 6CQ7
Enriched GO Terms of Interacting Partners?
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