KITLG and FLT3LG

Number of citations of the paper that reports this interaction (PubMedID 25241761)
10

Data Source:
BioGRID (imaging technique)
HPRD (in vivo)

		KITLG	FLT3LG
Description		KIT ligand	fms related receptor tyrosine kinase 3 ligand
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Integral Component Of Membrane Lamellipodium Filopodium	Extracellular Region Extracellular Space Cell Surface Membrane Integral Component Of Membrane Intrinsic Component Of External Side Of Plasma Membrane
	Molecular Function	Cytokine Activity Stem Cell Factor Receptor Binding Protein Binding Growth Factor Activity	Signaling Receptor Binding Cytokine Activity Receptor Tyrosine Kinase Binding
	Biological Process	MAPK Cascade Ovarian Follicle Development Neural Crest Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Myeloid Leukocyte Differentiation Cell Adhesion Positive Regulation Of Cell Proliferation Male Gonad Development Negative Regulation Of Mast Cell Apoptotic Process Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Positive Regulation Of MAP Kinase Activity Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mast Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation	MAPK Cascade Positive Regulation Of Protein Phosphorylation Signal Transduction Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Lymphocyte Differentiation Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Embryonic Hemopoiesis Positive Regulation Of Myoblast Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Positive Regulation Of Osteoclast Proliferation Positive Regulation Of Myoblast Fusion
Pathways			PI3K Cascade RAF/MAP kinase cascade FLT3 Signaling FLT3 Signaling STAT5 Activation
Drugs
Diseases		Familial progressive hyperpigmentation
GWAS		Blond vs non-blond hair color ( 26184321) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Hair color ( 23548203 29662168) Light vs. dark hair color ( 26184321) Nevus count ( 30429480) Red blood cell traits ( 23222517) Testicular cancer ( 19483682) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 19483681 28604728 28604732 23666239 23666240)	Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)
Interacting Genes		8 interacting genes: CLEC11A CMA1 CSF2 EPOR FLT3LG KIT PIK3CD UBE2V1	3 interacting genes: FLT3 KITLG PFN2
Entrez ID		4254	2323
HPRD ID		01698	02477
Ensembl ID		ENSG00000049130	ENSG00000090554
Uniprot IDs		A0A024RBC0 A0A024RBF5 P21583	B7ZLY4 M0QYM9 P49771
PDB IDs		1EXZ 1SCF 2E9W	1ETE 3QS7 3QS9
Enriched GO Terms of Interacting Partners?
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