MC4R and AGRP

Number of citations of the paper that reports this interaction (PubMedID 11747427)
18

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo, in vitro)

		MC4R	AGRP
Description		melanocortin 4 receptor	agouti related neuropeptide
Image
GO Annotations	Cellular Component	Nucleus Plasma Membrane Integral Component Of Membrane	Extracellular Space Golgi Lumen Neuronal Cell Body
	Molecular Function	Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Ubiquitin Protein Ligase Binding Neuropeptide Binding	Signaling Receptor Binding Neuropeptide Hormone Activity
	Biological Process	Diet Induced Thermogenesis Energy Reserve Metabolic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Feeding Behavior Regulation Of Metabolic Process Insulin Secretion Response To Insulin Positive Regulation Of Bone Resorption Negative Regulation Of Feeding Behavior Regulation Of Grooming Behavior	Neuropeptide Signaling Pathway Circadian Rhythm Feeding Behavior Adult Feeding Behavior Hormone-mediated Signaling Pathway Response To Insulin Eating Behavior Long-day Photoperiodism Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Positive Regulation Of Feeding Behavior
Pathways		Peptide ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
Diseases
GWAS		Antipsychotic drug-induced weight gain ( 22566560) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat percentage ( 26833246) Body mass index ( 28552196 24064335 23563607 26426971 19079260 19079261 26961502 24348519 23669352 24861553 18454148 31453325 28892062 25673413 20935630 29273807 28448500 25953783) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (age interaction) ( 25953783) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) C-reactive protein levels ( 30388399) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Childhood body mass index ( 26604143) Cobalt levels ( 26025379) Coffee consumption ( 31046077) Coronary artery disease ( 26343387) Daytime sleep phenotypes ( 27126917) Dentures ( 31235808) Diastolic blood pressure ( 27841878) Fat body mass ( 24064335) Fatty acid desaturase activity (serum) ( 30453627) Femoral neck bone mineral density ( 30172743) Free thyroxine concentration ( 30367059) Hand grip strength ( 29691431) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Height ( 20881960 25282103 25429064 31562340) Hip circumference ( 28552196 31453325 25673412) Hip circumference variance ( 31453325) Metabolic syndrome ( 31589552) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obese vs. thin ( 30677029) Obesity ( 23563607 19151714) Obesity (early onset extreme) ( 20421936 23563609) Obesity (extreme) ( 30677029) Obesity-related traits ( 22013104) Systolic blood pressure ( 30224653) Total body bone mineral density ( 30172743) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 22885922 24509480 30054458 30297969 30718926 28869590) Ulna and radius bone mineral density ( 30172743) Urate levels ( 31578528 23263486) Waist circumference ( 28552196 19557197 31453325 25673412) Waist circumference and related phenotypes ( 18454146) Waist circumference variance ( 31453325) Waist-hip ratio ( 25673412) Weight ( 19079260)	Blood protein levels ( 30072576 29875488 28240269)
Interacting Genes		9 interacting genes: AGRP ASIP ATRNL1 GRK2 IL1RAP MC1R NPY POMC PRKACA	4 interacting genes: GHRL MC3R MC4R MC5R
Entrez ID		4160	181
HPRD ID		01116	09079
Ensembl ID		ENSG00000166603	ENSG00000159723
Uniprot IDs		P32245	C6SUN5 O00253
PDB IDs		2IQP 2IQR 2IQS 2IQU 2IQV 2IQW	1HYK 1MR0 2IQV
Enriched GO Terms of Interacting Partners?
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