MC1R and ASIP

Number of citations of the paper that reports this interaction (PubMedID 9058374)
25

Data Source:
HPRD (in vivo)

		MC1R	ASIP
Description		melanocortin 1 receptor	agouti signaling protein
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Space Cell
	Molecular Function	Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Ubiquitin Protein Ligase Binding	Signaling Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development UV Protection Positive Regulation Of Protein Kinase A Signaling Sensory Perception Of Pain Negative Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Melanin Biosynthetic Process Pigmentation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Kinase B Signaling UV-damage Excision Repair Positive Regulation Of Protein Kinase C Signaling	Generation Of Precursor Metabolites And Energy Signal Transduction Cell-cell Signaling Adult Feeding Behavior Hormone-mediated Signaling Pathway Melanosome Transport Melanosome Organization Regulation Of Molecular Function, Epigenetic Melanin Biosynthetic Process Positive Regulation Of Melanin Biosynthetic Process Genetic Imprinting
Pathways		Peptide ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Afamelanotide CZEN 002
Diseases
GWAS		Basal cell carcinoma ( 21700618 31174203 27539887) Black vs. non-black hair color ( 26184321) Black vs. red hair color ( 18483556) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Cutaneous squamous cell carcinoma ( 27424798) Facial pigmentation ( 25705849) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627 29662168) Hair morphology traits ( 30166351) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Low tan response ( 29739929) Melanoma ( 21983787 28212542 24980573 19578364) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 30429480) Non-melanoma skin cancer ( 23548203 29739929) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Perceived skin darkness ( 25963972) Red vs non-red hair color ( 17952075 26184321) Red vs. brown/black hair color ( 30531825) Skin aging (microtopography measurement) ( 28502801) Skin colour saturation ( 25963972) Skin pigmentation ( 30664655) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 17952075 25963972) Squamous cell carcinoma ( 26829030) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 27723757 22561518)	Blood protein levels ( 30072576 29875488) Breast cancer ( 22976474) Burning and freckling ( 18488028) Facial pigmentation ( 25705849) Freckles ( 18488028) Freckling ( 20585627) Hair color ( 20585627) Low tan response ( 29739929) Melanoma ( 21983787 28212542) Nevus count or cutaneous melanoma ( 30429480) Non-melanoma skin cancer ( 29739929) Red vs. non-red hair color ( 18488028) Skin colour saturation ( 25963972) Skin pigmentation ( 28300201) Skin sensitivity to sun ( 25963972 18488028) Tanning ( 23548203) Vitiligo ( 27723757)
Interacting Genes		3 interacting genes: ASIP MC4R POMC	6 interacting genes: F11R MC1R MC2R MC3R MC4R MC5R
Entrez ID		4157	434
HPRD ID		01118	02562
Ensembl ID		ENSG00000258839	ENSG00000101440
Uniprot IDs		Q01726 Q1JUL4	P42127
PDB IDs			1Y7J 1Y7K 2IQW 2KZA 2L1J
Enriched GO Terms of Interacting Partners?
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