MATN2 and DVL3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MATN2	DVL3
Description		matrilin 2	dishevelled segment polarity protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Basement Membrane Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix	Nuclear Chromatin Cytosol
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Protease Binding Signaling Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Rac GTPase Binding
	Biological Process	Neuron Migration Growth Plate Cartilage Chondrocyte Morphogenesis Axon Guidance Biological_process Glial Cell Migration Dendrite Regeneration Response To Axon Injury	Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Response To Drug Positive Regulation Of JUN Kinase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Transcription, DNA-templated Protein Stabilization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Neuron Projection Arborization Regulation Of Cellular Protein Localization Beta-catenin Destruction Complex Disassembly
Pathways			TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Diffusing capacity of carbon monoxide ( 30694715) Erectile dysfunction ( 30583798)	Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Major depressive disorder ( 22472876)
Interacting Genes		17 interacting genes: ATXN1 ATXN1L ATXN7 CACNA1A CBFA2T3 COL1A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 DVL3 FBN2 FN1 MATN1 MATN4	49 interacting genes: ADAP1 AXIN1 BAHD1 C8orf33 CCNK CSNK1D CSNK1E CSNK2A1 CTNNB1 DAB2 DIDO1 DPPA2 DVL1 ENKD1 FAM13C KAT7 KLF3 KLHL12 LNX1 LRRK2 LY6H MARK2 MATN2 NKD1 NOL12 NXF1 PIK3CB PITX1 PLN PPM1A PPP2CA PRPF3 PSMF1 RAB18 RPS10 RWDD2B SNX22 STOM SYT6 TNFAIP8L1 UTP3 VANGL1 WT1 YTHDC1 ZBTB48 ZNF264 ZNF408 ZNF512B ZNF697
Entrez ID		4147	1857
HPRD ID		03660	03222
Ensembl ID		ENSG00000132561	ENSG00000161202
Uniprot IDs		A0A140VKH7 O00339 Q8N2G3	Q92997 Q9UG07
PDB IDs
Enriched GO Terms of Interacting Partners?
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