LTBP1 and IGFBP5

Number of citations of the paper that reports this interaction (PubMedID 12962157)
7

Data Source:
BioGRID (pull down)

		LTBP1	IGFBP5
Description		latent transforming growth factor beta binding protein 1	insulin like growth factor binding protein 5
Image
GO Annotations	Cellular Component	Microfibril Extracellular Region Endoplasmic Reticulum Lumen Extracellular Matrix Protein-containing Complex Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex
	Molecular Function	Transforming Growth Factor Beta-activated Receptor Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Transforming Growth Factor Beta Binding Microfibril Binding	Fibronectin Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Ventricular Septum Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Sequestering Of TGFbeta In Extracellular Matrix Aorta Development Post-translational Protein Modification Cellular Protein Metabolic Process Coronary Vasculature Development Regulation Of Transforming Growth Factor Beta Activation	Regulation Of Cell Growth Osteoblast Differentiation Signal Transduction Female Pregnancy Aging Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Intracellular Signal Transduction Glucose Homeostasis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Growth Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Mammary Gland Involution Response To Growth Hormone Cellular Response To CAMP Cellular Response To Organic Cyclic Compound Negative Regulation Of Muscle Tissue Development Negative Regulation Of Skeletal Muscle Hypertrophy Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Molecules associated with elastic fibres Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Carpal tunnel syndrome ( 30833571) Central corneal thickness ( 29760442) Diverticular disease ( 30177863) Height ( 28552196 20881960 25282103 25429064 19893584 23563607 31562340 20189936) Hip circumference adjusted for BMI ( 25673412) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Immune response to smallpox vaccine (IL-6) ( 22610502) Intraocular pressure ( 29617998 29785010 29235454) Knee osteoarthritis ( 30374069) Male-pattern baldness ( 28196072) Optic disc size ( 31809533) Rosacea symptom severity ( 29771307) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Blood protein levels ( 30072576 29875488) Breast cancer ( 29059683) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) FEV1 ( 30804560) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Height ( 31562340) Hypothyroidism ( 27182965) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497) Pulse pressure ( 27841878) Serum thyroid-stimulating hormone levels ( 25436638) Thyroid hormone levels ( 23408906) Visceral fat ( 22589738)
Interacting Genes		10 interacting genes: ATN1 CACNA1A FBN1 FBN2 FN1 IGFBP3 IGFBP5 ITGB5 TGFB1 TGM2	21 interacting genes: ADAM12 BAG6 CREB3 CSDE1 F2 FHL2 FN1 IGF1 IGF2 IGFALS KPNB1 LMNA LTBP1 PAPPA2 PNO1 RASSF1 SERPINE1 SPP1 TF THBS1 VTN
Entrez ID		4052	3488
HPRD ID		01039	00901
Ensembl ID		ENSG00000049323	ENSG00000115461
Uniprot IDs		B7ZLY3 Q14766	P24593
PDB IDs		1KSQ	1BOE 1H59
Enriched GO Terms of Interacting Partners?
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