LOXL1 and MFGE8

		LOXL1	MFGE8
Description		lysyl oxidase like 1	milk fat globule EGF and factor V/VIII domain containing
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Basement Membrane Extracellular Space Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen External Side Of Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle
	Molecular Function	Protein-lysine 6-oxidase Activity Copper Ion Binding	Phosphatidylserine Binding Integrin Binding Extracellular Matrix Structural Constituent Phosphatidylethanolamine Binding
	Biological Process	Peptidyl-lysine Oxidation Protein Deamination Extracellular Matrix Organization Response To Lipopolysaccharide Aorta Development Oxidation-reduction Process	Angiogenesis Phagocytosis, Recognition Phagocytosis, Engulfment Cell Adhesion Single Fertilization Apoptotic Cell Clearance Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Phagocytosis
Pathways		Elastic fibre formation Crosslinking of collagen fibrils	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Amyloid fiber formation
Drugs
Diseases
GWAS		Aortic root size ( 19584346) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Coronary artery disease ( 29212778) Diverticular disease ( 30177863) Exfoliation glaucoma or exfoliation syndrome ( 24938310) Exfoliation syndrome ( 25706626) Glaucoma (exfoliation) ( 17690259) Hand grip strength ( 29691431) Height ( 28552196 23563607 31562340) Joint mobility (Beighton score) ( 27182965) Pseudoexfoliation syndrome ( 29278698) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Blood protein levels ( 30072576 29875488 28240269) Coronary artery disease ( 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Height ( 31562340) Pulse pressure ( 27841878) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		4 interacting genes: ATXN1 ELN FBLN5 MFGE8	7 interacting genes: LOXL1 MRPL46 MRPS11 PRLR PSTPIP1 TM6SF1 TRIP13
Entrez ID		4016	4240
HPRD ID		08861	03789
Ensembl ID		ENSG00000129038	ENSG00000140545
Uniprot IDs		Q08397	B3KTQ2 B4E396 Q08431
PDB IDs
Enriched GO Terms of Interacting Partners?
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