LBP and CD14

Number of citations of the paper that reports this interaction (PubMedID 12417309)
19

Data Source:
HPRD (in vitro)

		LBP	CD14
Description		lipopolysaccharide binding protein	CD14 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Membrane Extracellular Exosome	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Secretory Granule Membrane Anchored Component Of External Side Of Plasma Membrane Membrane Raft Lipopolysaccharide Receptor Complex Extracellular Exosome
	Molecular Function	Lipopolysaccharide Binding Signaling Receptor Binding Protein Binding Lipoteichoic Acid Binding Lipopeptide Binding	Lipopolysaccharide Binding Opsonin Receptor Activity Protein Binding Peptidoglycan Receptor Activity Lipoteichoic Acid Binding Lipopeptide Binding
	Biological Process	Toll-like Receptor Signaling Pathway Leukocyte Chemotaxis Involved In Inflammatory Response Macrophage Activation Involved In Immune Response Acute-phase Response Cellular Defense Response Opsonization Lipopolysaccharide Transport Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Detection Of Molecule Of Bacterial Origin Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Macromolecule Localization Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Macrophage Activation Innate Immune Response Positive Regulation Of Cytolysis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Receptor-mediated Endocytosis Phagocytosis Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Heat Lipopolysaccharide-mediated Signaling Pathway Response To Magnesium Ion Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Neutrophil Degranulation Innate Immune Response Response To Ethanol Positive Regulation Of Endocytosis Positive Regulation Of Cytokine Secretion Response To Electrical Stimulus Necroptotic Process Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Apoptotic Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Interleukin-8 Secretion
Pathways		Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling	ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases			Asthma
GWAS		Blood protein levels ( 30072576 29875488) Periodontitis (DPAL) ( 24024966)	Blood protein levels ( 30072576) Schizophrenia ( 29483656)
Interacting Genes		18 interacting genes: APOA1 BAG6 BST1 C4BPA CAMP CBFA2T2 CD14 CFHR1 FTH1 HSPB1 PRDX4 PSMA3 PYCR3 RPS21 SETD1A SMAD3 TRA2A TSC22D4	15 interacting genes: ARFGAP3 CD55 GJB2 IRAK3 ITGB2 LBP LGALS3BP LTF POLR2J PPP3R2 REEP5 TLR2 TLR3 TLR4 TNFRSF1B
Entrez ID		3929	929
HPRD ID		07175	01151
Ensembl ID		ENSG00000129988	ENSG00000170458
Uniprot IDs		P18428 Q8TCF0	P08571
PDB IDs			4GLP
Enriched GO Terms of Interacting Partners?
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