ARHGAP1 and BNIP2

Number of citations of the paper that reports this interaction (PubMedID 10954711)
12

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ARHGAP1	BNIP2
Description		Rho GTPase activating protein 1	BCL2 interacting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Sorting Endosome	Nuclear Envelope Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	SH3/SH2 Adaptor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding Rab GTPase Binding Cadherin Binding	Exopolyphosphatase Activity GTPase Activator Activity Calcium Ion Binding Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Signal Transduction Endosomal Transport Transferrin Transport Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Endocytic Recycling	Polyphosphate Catabolic Process Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Muscle Cell Differentiation
Pathways		Rho GTPase cycle	Myogenesis Myogenesis
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Bone mineral density (hip) ( 19801982) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Femoral neck bone mineral density ( 22504420) Neurociticism ( 29500382) Reaction time ( 29844566) Schizophrenia ( 29483656) Suffering from nerves ( 29500382)	Gut microbiota (bacterial taxa) ( 27723756)
Interacting Genes		23 interacting genes: ADGRB2 AGTRAP BNIP2 BNIPL CDC42 CHEK2 EPB41L1 HMGCR HSP90AB1 ITPR1 KIF1B MTNR1B PIK3R1 PTPN11 RAC1 RASA1 RHOA RHOC SMARCD3 SRC TAX1BP1 TUBA4A WAS	14 interacting genes: ARHGAP1 ARHGAP8 BCL2 BNIPL CDC42 CREB3 FATE1 FGFR1 FRK KLC1 LMNA MYO5B NCBP1 UPK1B
Entrez ID		392	663
HPRD ID		04108	04481
Ensembl ID		ENSG00000175220	ENSG00000140299
Uniprot IDs		Q07960	J3KN59 Q12982
PDB IDs		1AM4 1GRN 1OW3 1RGP 1TX4 2NGR 5M6X 5M70 6R3V
Enriched GO Terms of Interacting Partners?
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