LAMC2 and FBLN2

Number of citations of the paper that reports this interaction (PubMedID 11733994)
31

Data Source:
HPRD (in vitro)

		LAMC2	FBLN2
Description		laminin subunit gamma 2	fibulin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-2 Complex Extracellular Space Cell Cortex Membrane Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Vesicle
	Molecular Function	Extracellular Matrix Structural Constituent Heparin Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding
	Biological Process	Cell Adhesion Motor Neuron Axon Guidance Positive Regulation Of Cell Proliferation Epidermis Development Animal Organ Morphogenesis Tissue Development Dendrite Development Extracellular Matrix Organization Positive Regulation Of Cell Migration Hemidesmosome Assembly	Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Acne (severe) ( 30542056) Blood protein levels ( 30072576 29875488) Clozapine-induced agranulocytosis ( 25187353) HDL cholesterol ( 21347282) Morning person ( 30696823) Systemic lupus erythematosus ( 21408207)	Bipolar disorder with mood-incongruent psychosis ( 23092984) Body mass index ( 26426971) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)
Interacting Genes		8 interacting genes: BMP1 COL7A1 CSF1R FBLN2 LAMB3 NID1 SCAP SLA2	23 interacting genes: ACAN ATN1 BCAN COL18A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 ELN FBN1 FN1 HSPG2 ITGB3 LAMA1 LAMA5 LAMC2 MRPS25 NID1 PRELP VCAN ZNF408
Entrez ID		3918	2199
HPRD ID		01031	00630
Ensembl ID		ENSG00000058085	ENSG00000163520
Uniprot IDs		Q13753	P98095 Q86V58 Q9Y3V7
PDB IDs
Enriched GO Terms of Interacting Partners?
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