INSC and PARD3

Number of citations of the paper that reports this interaction (PubMedID 16458856)
9

Data Source:
HPRD (in vivo)

		INSC	PARD3
Description		INSC spindle orientation adaptor protein	par-3 family cell polarity regulator
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Cortex Protein-containing Complex	Cell Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Endomembrane System Apical Plasma Membrane Cell Junction Protein-containing Complex Internode Region Of Axon Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Apical Junction Complex Axonal Growth Cone
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein Binding, Bridging	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Nervous System Development Asymmetric Cell Division Cell Differentiation Regulation Of Protein Stability	Microtubule Cytoskeleton Organization Protein Targeting To Membrane Cell Cycle Cell Adhesion Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Protein Localization Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Establishment Of Cell Polarity Positive Regulation Of Myelination Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Of Centrosome Localization Regulation Of Cellular Localization Protein-containing Complex Assembly Bicellular Tight Junction Assembly Establishment Of Epithelial Cell Polarity
Pathways			TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions
Drugs
Diseases
GWAS		Expressive vocabulary in infants ( 25226531) Heel bone mineral density ( 30598549 28869591) Menarche (age at onset) ( 23667675) Obesity-related traits ( 23251661)	Acute lymphoblastic leukemia (childhood) ( 19684603) Corneal astigmatism ( 30306274) Emphysema-related traits ( 20709820) Estimated glomerular filtration rate ( 31015462) Hip circumference adjusted for BMI ( 28552196) Lung function (FEV1/FVC) ( 30804560) Major depressive disorder ( 21621269) Schizophrenia ( 21682944)
Interacting Genes		5 interacting genes: GPSM1 GPSM2 LNX1 PARD3 PARD3B	28 interacting genes: CDC42 DYNLL1 F11R INSC LIMK2 NECTIN1 NECTIN3 PARD6A PARD6B PARD6G PATJ PLCB1 PLCB3 PNMA1 PRKCG PRKCI SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 YWHAB YWHAG YWHAH YWHAZ
Entrez ID		387755	56288
HPRD ID		18803	05994
Ensembl ID		ENSG00000188487	ENSG00000148498
Uniprot IDs		Q1MX18	Q8TEW0
PDB IDs		3SF4	2KOM
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?