KRT5 and ALOX12B

Number of citations of the paper that reports this interaction (PubMedID 10727209)
12

Data Source:
HPRD (two hybrid, in vivo)

		KRT5	ALOX12B
Description		keratin 5	arachidonate 12-lipoxygenase, 12R type
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Plasma Membrane Membrane Keratin Filament Extracellular Exosome	Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding	Arachidonate 12-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Lyase Activity Isomerase Activity Arachidonate 8(R)-lipoxygenase Activity Linoleate 9S-lipoxygenase Activity
	Biological Process	Cytoskeleton Organization Epidermis Development Keratinization Hemidesmosome Assembly Cornification	Protein Lipidation Sphingolipid Metabolic Process Positive Regulation Of Gene Expression Arachidonic Acid Metabolic Process Lipoxygenase Pathway Lipid Oxidation Positive Regulation Of MAPK Cascade Linoleic Acid Metabolic Process Ceramide Biosynthetic Process Hepoxilin Biosynthetic Process Oxidation-reduction Process Establishment Of Skin Barrier Positive Regulation Of Mucus Secretion
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope	Synthesis of 12-eicosatetraenoic acid derivatives
Drugs		Zinc
Diseases		Dowling-Degos disease Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic	Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS		Basal cell carcinoma ( 31174203 24403052 25855136 27539887) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)
Interacting Genes		17 interacting genes: ALOX12 ALOX12B APC DSP DST EVPL KIFC3 KRT1 KRT14 KRT15 KRT18 KRT31 KRT38 KRT40 PKP2 TCHP UBE3A	2 interacting genes: KRT5 LMNA
Entrez ID		3852	242
HPRD ID		01010	04772
Ensembl ID		ENSG00000186081	ENSG00000179477
Uniprot IDs		P13647	O75342
PDB IDs		3TNU
Enriched GO Terms of Interacting Partners?
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