KRTAP5-9 and BMP7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		KRTAP5-9	BMP7
Description		keratin associated protein 5-9	bone morphogenetic protein 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament	Extracellular Region Extracellular Space Vesicle Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding	Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding BMP Receptor Binding
	Biological Process	Epidermis Development Keratinization	Skeletal System Development Ossification Metanephros Development Ureteric Bud Development Mesoderm Formation Mesonephros Development Epithelial To Mesenchymal Transition Endocardial Cushion Formation Pericardium Morphogenesis Axon Guidance Embryonic Pattern Specification Positive Regulation Of Gene Expression Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Dendrite Development Neural Fold Elevation Formation Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization BMP Signaling Pathway Epithelial Cell Differentiation Hindbrain Development Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Estradiol Response To Vitamin D Positive Regulation Of Heterotypic Cell-cell Adhesion Protein Localization To Nucleus Negative Regulation Of Phosphorylation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of MAP Kinase Activity Response To Peptide Hormone Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Cardiac Muscle Tissue Development Branching Morphogenesis Of An Epithelial Tube Mesenchymal Cell Differentiation Neuron Projection Morphogenesis Cartilage Development Pharyngeal System Development Embryonic Skeletal Joint Morphogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Branching Involved In Salivary Gland Morphogenesis Mesenchyme Development Negative Regulation Of Cell Death Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Chorio-allantoic Fusion Heart Trabecula Morphogenesis Monocyte Aggregation Cellular Response To Hypoxia Cellular Response To BMP Stimulus Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Mesenchyme Morphogenesis Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Positive Regulation Of Dendrite Development Positive Regulation Of Hyaluranon Cable Assembly Negative Regulation Of NIK/NF-kappaB Signaling Allantois Development Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Removal Of Superoxide Radicals
Pathways		Keratinization	Molecules associated with elastic fibres
Drugs
Diseases
GWAS			Cerebrospinal P-tau181p levels ( 28247064) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortisol levels (saliva) ( 28843169) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Microalbuminuria in type 1 diabetes ( 31537649) Monobrow ( 27182965) Nose size ( 27182965) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288) Response to citalopram treatment ( 19846067) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) White blood cell types ( 21738478)
Interacting Genes		107 interacting genes: ABHD17A ADAMTSL4 ALPP ATG9A BEX2 BMP7 C10orf62 C11orf87 CATSPER1 CHIC2 CHRD CKS1B CNNM3 COMT CRCT1 CREB5 CTSZ CXCL16 DHRS1 DMRT3 DOCK2 FAH FAM124B FAM161A FAM74A4 FAM76B GLRX3 GNE HOXA1 HOXB9 HPCAL1 HSPD1 JOSD1 KLHL38 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 KRTAP9-4 LCE1B LCE2A LCE3C LCE3E LCE4A LY6H MAPKBP1 MEOX2 NAXD NCLN NECTIN2 NLK NMU NOTCH2NLA NPBWR2 NPDC1 NTAQ1 NTM NTN4 NUFIP2 OTX1 P2RX4 PCSK5 PFKL PGLS POM121L8P PRKAB2 PSMA1 PTPMT1 RAMP3 RGS20 RNF111 SCARB1 SDC3 SDCBP SHFL SLC22A23 SLC25A10 SMCP SPATC1L SPG7 SPINK2 SPRY2 TBC1D10C TBC1D16 TCEA2 TCEANC TOMM22 TYRO3 YIPF3 ZBTB24 ZFYVE21 ZNF124 ZNF266 ZNF417 ZNF439 ZNF581 ZNF587	22 interacting genes: ACTN4 ACVR1 ACVR2A ACVR2B BMPR1A BMPR1B BMPR2 CHRDL2 ENG GDF7 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP5-9 MTUS2 NCOA3 NOG NOTCH2NLA SOSTDC1 TDGF1 TRIM27
Entrez ID		3846	655
HPRD ID		01008	00212
Ensembl ID		ENSG00000254997	ENSG00000101144
Uniprot IDs		P26371	A8K571 P18075
PDB IDs			1BMP 1LX5 1LXI 1M4U
Enriched GO Terms of Interacting Partners?
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