ARG2 and ARG1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		ARG2	ARG1
Description		arginase 2	arginase 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrial Outer Membrane Cytosol Azurophil Granule Lumen Specific Granule Lumen Neuron Projection Neuronal Cell Body
	Molecular Function	Arginase Activity Manganese Ion Binding	Arginase Activity Protein Binding Manganese Ion Binding Identical Protein Binding
	Biological Process	Urea Cycle Ureteric Bud Development Adaptive Immune Response Negative Regulation Of Type 2 Immune Response Nitric Oxide Biosynthetic Process Striated Muscle Contraction Arginine Catabolic Process To Ornithine Negative Regulation Of Tumor Necrosis Factor Production Innate Immune Response Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Chemokine (C-C Motif) Ligand 4 Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Negative Regulation Of Defense Response To Bacterium Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor Secretion Negative Regulation Of Interleukin-17 Secretion Negative Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Interleukin-13 Secretion Positive Regulation Of Cellular Senescence	Urea Cycle Liver Development Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Arginine Catabolic Process Aging Response To Herbicide Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Regulation Of L-arginine Import Response To Amine Arginine Catabolic Process To Ornithine Lung Development Collagen Biosynthetic Process Response To Vitamin A Response To Vitamin E Negative Regulation Of T Cell Proliferation Defense Response To Protozoan Response To Amino Acid Neutrophil Degranulation Innate Immune Response Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Response To Axon Injury Response To Methylmercury Mammary Gland Involution Maternal Process Involved In Female Pregnancy Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Positive Regulation Of Neutrophil Mediated Killing Of Fungus Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Glucagon Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Urea cycle	Neutrophil degranulation Urea cycle
Drugs		L-Arginine Ornithine S-2-(Boronoethyl)-L-Cysteine	Ornithine 2(S)-Amino-6-Boronohexanoic Acid nor-NOHA Dinor-N(Omega)-Hydroxy-L-Arginine S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine N-Omega-Hydroxy-L-Arginine S-2-(Boronoethyl)-L-Cysteine Urea Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine S,S-(2-Hydroxyethyl)Thiocysteine DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID S-propylamine-L-cysteine Manganese
Diseases			Hyperargininemia
GWAS			Blood protein levels ( 30072576) C-reactive protein levels ( 24763700) Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 29403010) Obesity ( 21552555) Type 2 diabetes ( 30054458)
Interacting Genes		2 interacting genes: ARG1 STK11	5 interacting genes: ALDH4A1 ARG2 FLOT1 NOS1 UCHL5
Entrez ID		384	383
HPRD ID		00143	01947
Ensembl ID		ENSG00000081181	ENSG00000118520
Uniprot IDs		A0A024R6A0 P78540	P05089
PDB IDs		1PQ3 4HZE 4I06 4IE2 4IE3 4IXU 4IXV 6Q37 6Q39	1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE 3THH 3THJ 4FCI 4FCK 4GSM 4GSV 4GSZ 4GWC 4GWD 4HWW 4HXQ 4IE1
Enriched GO Terms of Interacting Partners?
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