KLC1 and KLC2

Number of citations of the paper that reports this interaction (PubMedID 26496610)
285

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		KLC1	KLC2
Description		kinesin light chain 1	kinesin light chain 2
Image
GO Annotations	Cellular Component	Cytosol Kinesin Complex Microtubule Membrane Growth Cone Cytoplasmic Vesicle	Nucleoplasm Mitochondrion Cytosol Kinesin Complex Microtubule Plasma Membrane Membrane Kinesin I Complex Protein-containing Complex
	Molecular Function	Motor Activity Microtubule Motor Activity Protein Binding	Microtubule Motor Activity Protein Binding Kinesin Binding Cadherin Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To ER Microtubule-based Movement Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Stress Granule Disassembly	Retrograde Vesicle-mediated Transport, Golgi To ER Microtubule-based Movement Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Pathways		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins	MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 28892062 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061) Smoking behaviour (cigarette pack-years) ( 30679032) Urate levels ( 31578528)	Bipolar disorder ( 21926972 31043756) Metabolite levels ( 23823483)
Interacting Genes		21 interacting genes: APP BNIP2 CCDC114 CLSTN1 HSPB1 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 NIN ODF1 PCM1 PLEKHM2 SNCA SPAG9 YWHAB	16 interacting genes: AIMP2 APP CLSTN1 COIL DDX41 KIF2A KLC1 KLC4 LRRK2 MAPK8IP3 PIK3R3 PRC1 S100A8 YWHAG YWHAQ YWHAZ
Entrez ID		3831	64837
HPRD ID		02489	13917
Ensembl ID		ENSG00000126214	ENSG00000174996
Uniprot IDs		Q07866 Q7RTQ2	Q9H0B6
PDB IDs		3NF1 5OJ8	3CEQ 3EDT
Enriched GO Terms of Interacting Partners?
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