KCNK1 and SENP1

Number of citations of the paper that reports this interaction (PubMedID 15820677)
85

Data Source:
HPRD (in vivo)

		KCNK1	SENP1
Description		potassium two pore domain channel subfamily K member 1	SUMO specific peptidase 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Apical Plasma Membrane Cell Junction Dendrite Brush Border Membrane Potassium Channel Complex Perikaryon Intracellular Membrane-bounded Organelle Recycling Endosome Synaptic Membrane Inward Rectifier Potassium Channel Complex	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane
	Molecular Function	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding Potassium Ion Leak Channel Activity Identical Protein Binding	Endopeptidase Activity Protein Binding SUMO-specific Protease Activity SUMO-specific Isopeptidase Activity
	Biological Process	Potassium Ion Transport Stabilization Of Membrane Potential Response To Nicotine Sodium Ion Transmembrane Transport Regulation Of Resting Membrane Potential Cardiac Conduction Potassium Ion Transmembrane Transport	Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Definitive Erythrocyte Differentiation Protein Sumoylation Protein Desumoylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Signaling Pathway
Pathways		Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Phase 4 - resting membrane potential	SUMO is proteolytically processed
Drugs		Ibutilide Quinidine Quinidine barbiturate
Diseases
GWAS		Cognitive function ( 28808816) Diabetic retinopathy ( 21441570) Periodontal microbiota ( 22699663) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Glycated hemoglobin levels ( 28898252) Macular thickness ( 30535121) Rheumatoid arthritis ( 30891314)
Interacting Genes		6 interacting genes: CREB3 KRTAP10-3 LMNA SENP1 TCIRG1 UBE2I	23 interacting genes: APP CAV3 GCM1 HDAC1 HIPK2 KCNK1 NACC1 PARP1 PIAS3 PIM1 PML PRIM1 RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28
Entrez ID		3775	29843
HPRD ID		03447	07153
Ensembl ID		ENSG00000135750	ENSG00000079387
Uniprot IDs		A0A024R3T2 O00180	Q6N001 Q7Z3G1 Q9P0U3
PDB IDs		3UKM	2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ
Enriched GO Terms of Interacting Partners?
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