JAG2 and NOTCH2

Number of citations of the paper that reports this interaction (PubMedID 10958687)
40

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		JAG2	NOTCH2
Description		jagged canonical Notch ligand 2	notch receptor 2
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Membrane Receptor Complex
	Molecular Function	Notch Binding Calcium Ion Binding Protein Binding Growth Factor Activity	Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity NF-kappaB Binding
	Biological Process	Skeletal System Development In Utero Embryonic Development Respiratory System Process Notch Signaling Pathway Spermatogenesis Auditory Receptor Cell Fate Commitment Morphogenesis Of Embryonic Epithelium Cell Differentiation Regulation Of Cell Adhesion T Cell Differentiation Regulation Of Cell Proliferation Odontogenesis Of Dentin-containing Tooth Gamma-delta T Cell Differentiation Thymic T Cell Selection Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Notch Signaling Pathway Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Cell Fate Determination Heart Looping Morphogenesis Of An Epithelial Sheet Marginal Zone B Cell Differentiation Inflammatory Response To Antigenic Stimulus Pulmonary Valve Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process Humoral Immune Response Cell Cycle Arrest Notch Signaling Pathway Multicellular Organism Development Nervous System Development Animal Organ Morphogenesis Negative Regulation Of Gene Expression Positive Regulation Of Keratinocyte Proliferation Stem Cell Population Maintenance Hemopoiesis Embryonic Limb Morphogenesis Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intrahepatic Bile Duct Development Wound Healing Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Growth Rate Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Notch Signaling Involved In Heart Development Positive Regulation Of ERK1 And ERK2 Cascade Left/right Axis Specification Proximal Tubule Development Glomerular Visceral Epithelial Cell Development Glomerular Capillary Formation Hepatocyte Proliferation Interleukin-4 Secretion Cholangiocyte Proliferation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Osteoclast Development
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus	Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases			Alagille syndrome Type II diabetes mellitus Hajdu-Cheney syndrome
GWAS			Blood protein levels ( 30072576) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 18372903 30054458 30297969)
Interacting Genes		8 interacting genes: ATN1 ATXN7 CACNA1A GFI1B MIB2 NOTCH1 NOTCH2 NOTCH3	28 interacting genes: CNTN1 CRKL CST6 DLL1 DTX1 EGFL7 EPSTI1 GSK3B IL13RA2 IL24 ITIH5 JAG1 JAG2 KLK5 LFNG LRATD2 MAML1 MAML2 MAML3 MFNG MTA3 MYOC PSEN1 PSEN2 PSMC3IP RBPJ SMAD1 ST14
Entrez ID		3714	4853
HPRD ID		03981	02606
Ensembl ID		ENSG00000184916	ENSG00000134250
Uniprot IDs		Q9Y219	Q04721 Q6IQ50 Q9UFD5
PDB IDs		5MW5 5MW7 5MWF	2OO4 5MWB
Enriched GO Terms of Interacting Partners?
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