ARAF and TESK1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ARAF	TESK1
Description		A-Raf proto-oncogene, serine/threonine kinase	testis associated actin remodelling kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Cellular_component Mitochondrion Cytosol	Nucleus Cytoplasm Cytosol Cytoplasmic Vesicle
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	MAPK Cascade Cellular Protein Modification Process Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process	Spermatogenesis Peptidyl-tyrosine Phosphorylation Actin Cytoskeleton Organization Negative Regulation Of Protein Autophosphorylation Regulation Of Protein Localization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Protein Serine/threonine Kinase Activity
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs		ATP
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Interacting Genes		59 interacting genes: AGTRAP AKT1 ASS1 BAD BECN1 BRAF CCND2 CDK4 CDK6 CDKN2B CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 EPHA2 FGFR4 GLIS2 GNA12 HRAS IRAK2 IRF7 KLHL12 KRAS LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MLH1 MYC MYO18A NELFCD NF2 NUDT14 PBK PDGFRB PIK3CA PIK3R1 PKM PRPF6 RABGGTB RASSF1 RGS12 RRAS RRAS2 SFN STK11 TEKT4P2 TESK1 TIMM44 TIRAP TP53 TSC1 WNK1 YWHAG YWHAZ	8 interacting genes: ABCB4 ARAF CFL1 IL17RA PFKL SPRY4 YWHAB YY1
Entrez ID		369	7016
HPRD ID		02405	03470
Ensembl ID		ENSG00000078061	ENSG00000107140
Uniprot IDs		A0A024R178 P10398 Q96II5	Q15569 Q8NFJ4
PDB IDs		1WXM 2MSE
Enriched GO Terms of Interacting Partners?
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