ITGA2 and AUP1

Number of citations of the paper that reports this interaction (PubMedID 12042322)
9

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ITGA2	AUP1
Description		integrin subunit alpha 2	AUP1 lipid droplet regulating VLDL assembly factor
Image
GO Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Integrin Alpha2-beta1 Complex Axon Terminus Basal Part Of Cell Perinuclear Region Of Cytoplasm	Hrd1p Ubiquitin Ligase ERAD-L Complex Membrane Integral Component Of Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Virus Receptor Activity Integrin Binding Protein Binding Collagen Binding Collagen Receptor Activity Laminin Binding Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion	Protein Binding Ubiquitin Binding Ubiquitin-protein Transferase Activator Activity
	Biological Process	Response To Hypoxia Positive Regulation Of Leukocyte Migration Substrate-dependent Cell Migration Hypotonic Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Female Pregnancy Blood Coagulation Cell Proliferation Animal Organ Morphogenesis Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Response To Amine Response To Muscle Activity Positive Regulation Of Smooth Muscle Cell Migration Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of Cell Projection Organization Cell-substrate Adhesion Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Binding Response To L-ascorbic Acid Cell Adhesion Mediated By Integrin Collagen-activated Signaling Pathway Response To Drug Positive Regulation Of DNA Binding Skin Morphogenesis Establishment Of Protein Localization Positive Regulation Of Translation Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Contraction Viral Entry Into Host Cell Focal Adhesion Assembly Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Positive Chemotaxis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Phagocytosis, Engulfment Hepatocyte Differentiation Response To Parathyroid Hormone Cellular Response To Mechanical Stimulus Cellular Response To Estradiol Stimulus	Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Regulation Of Catalytic Activity
Pathways		Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions ECM proteoglycans CHL1 interactions Platelet Adhesion to exposed collagen MET activates PTK2 signaling
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Type 2 diabetes ( 30130595)
Interacting Genes		14 interacting genes: ACTA1 APP AUP1 CD9 COL1A1 COL1A2 COL8A1 FBN2 HSPG2 ITGB1 LAMA1 MMP1 RABIF TSC22D2	7 interacting genes: ITGA1 ITGA2 ITGA2B ITGA5 ITGAM ITGAV RNF11
Entrez ID		3673	550
HPRD ID		01893	03892
Ensembl ID		ENSG00000164171	ENSG00000115307
Uniprot IDs		P17301	Q9Y679
PDB IDs		1AOX 1DZI 1PQB 1V7P 4BJ3 5HJ2 5THP 6ND8 6ND9 6NDA 6NDB 6NDC 6NDD 6NDE 6NDF 6NDG 6NDH	2EKF
Enriched GO Terms of Interacting Partners?
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