IRF7 and LTN1

Number of citations of the paper that reports this interaction (PubMedID 21903422)
114

Data Source:
BioGRID (affinity chromatography technology, pull down)

		IRF7	LTN1
Description		interferon regulatory factor 7	listerin E3 ubiquitin protein ligase 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane	Cytosol RQC Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding	Protein Binding Zinc Ion Binding Ribosomal Large Subunit Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Adaptive Immune Response Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Response To Virus Immunoglobulin Mediated Immune Response Establishment Of Viral Latency Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-alpha Production Interferon-beta Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Innate Immune Response Type I Interferon Biosynthetic Process Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		DEx/H-box helicases activate type I IFN and inflammatory cytokines production Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 27399966 26502338 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989)	High light scatter reticulocyte percentage of red cells ( 27863252) Hip circumference ( 28552196) Initial pursuit acceleration in psychotic disorders ( 29064472) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		27 interacting genes: ACADS AIP ARAF CCDC47 CREBBP EP300 GCLM INSR IRAK1 IRF3 KAT2A KAT2B LTN1 MAVS MYD88 PALD1 PIAS4 SOCS1 SOCS3 TBK1 TICAM1 TICAM2 TLK2 TP53 TRAF6 TRIM28 TRMT61B	8 interacting genes: HES4 IRF7 STING1 TIRAP UBC UBE2D1 UBE2D2 UBE2L3
Entrez ID		3665	26046
HPRD ID		05441	10327
Ensembl ID		ENSG00000185507	ENSG00000198862
Uniprot IDs		A0A024RCA2 B4E1B1 M9RSF4 Q92985	O94822
PDB IDs		2O61	3J92
Enriched GO Terms of Interacting Partners?
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