IRF4 and YTHDC2

Number of citations of the paper that reports this interaction (PubMedID 21903422)
114

Data Source:
BioGRID (affinity chromatography technology, pull down)

		IRF4	YTHDC2
Description		interferon regulatory factor 4	YTH domain containing 2
Image
GO Annotations	Cellular Component	Nuclear Nucleosome Nuclear Chromatin Nucleus Nucleoplasm Cytosol Membrane	Intracellular Nucleus Cytoplasm Endoplasmic Reticulum Ribonucleoprotein Granule
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding	RNA Binding Protein Binding ATP Binding RNA-dependent ATPase Activity 3'-5' RNA Helicase Activity RNA Polymerase Binding N6-methyladenosine-containing RNA Binding
	Biological Process	Immune System Process Cytokine-mediated Signaling Pathway Negative Regulation Of Toll-like Receptor Signaling Pathway T Cell Activation Defense Response To Protozoan Myeloid Dendritic Cell Differentiation Positive Regulation Of DNA Binding Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-13 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Regulation Of T-helper Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway T-helper 17 Cell Lineage Commitment Positive Regulation Of Cold-induced Thermogenesis	Spermatid Development Response To Tumor Necrosis Factor Positive Regulation By Host Of Viral Genome Replication Oocyte Development Meiotic Cell Cycle Germline Cell Cycle Switching, Mitotic To Meiotic Cell Cycle Response To Interleukin-1
Pathways		Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Basal cell carcinoma ( 31174203 27539887) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs non-blond hair color ( 26184321) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Celiac disease ( 22057235 20190752) Chronic lymphocytic leukemia ( 18758461 28165464 26956414 24292274 23770605) Crohn's disease ( 26192919) Cutaneous squamous cell carcinoma ( 27424798) Eye color ( 20585627 30664655) Eye color (brightness) ( 30664655) Eye color traits ( 30166351) Facial pigmentation ( 25705849) Feeling nervous ( 29500382) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627 30664655 29662168 26926045) Hair greying ( 26926045) Hair morphology traits ( 30166351) Hematology traits ( 23303382) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Limited cutaneous systemic scleroderma ( 29293537) Low tan response ( 29739929) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Lymphocyte counts ( 27863252) Male-pattern baldness ( 29146897 27182965 28196072) Medication use (thyroid preparations) ( 31015401) Melanoma ( 28212542) Monobrow ( 27182965) Nevus count ( 30429480) Non-melanoma skin cancer ( 23548203 29739929) Progressive supranuclear palsy ( 21685912) Psoriasis ( 25903422 25574825 23143594) Rheumatoid arthritis ( 30423114 24390342) Rosacea symptom severity ( 29771307) Skin aging (microtopography measurement) ( 28502801) Skin colour saturation ( 25963972) Skin pigmentation ( 30664655) Skin pigmentation traits ( 30166351) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Sunburns ( 23548203) Tanning ( 23548203) Vitiligo ( 27723757)	F-cell distribution in sickle cell anaemia ( 21326311) Metabolite levels ( 23823483) Type 2 diabetes ( 30054458)
Interacting Genes		20 interacting genes: BATF BCL6 ELP1 ETV7 FKBP4 HOXB13 HOXC11 IRAK1 MYD88 NFATC2 PRDM1 PROX1 SPI1 SPIB STAT6 TLK2 TOP1 TRAF2 USP4 YTHDC2	3 interacting genes: IRAK1 IRF4 SRPK2
Entrez ID		3662	64848
HPRD ID		03543	11690
Ensembl ID		ENSG00000137265	ENSG00000047188
Uniprot IDs		Q15306	Q9H6S0
PDB IDs		2DLL	2YU6
Enriched GO Terms of Interacting Partners?
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