INPP1 and NR1D1

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid, two hybrid)

		INPP1	NR1D1
Description		inositol polyphosphate-1-phosphatase	nuclear receptor subfamily 1 group D member 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Body Cell Junction Dendrite Dendritic Spine RNA Polymerase II Transcription Factor Complex
	Molecular Function	Inositol-1,4-bisphosphate 1-phosphatase Activity Protein Binding Metal Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Transcription Corepressor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Heme Binding Nuclear Receptor Transcription Coactivator Activity Signaling Receptor Activity Transcription Regulatory Region DNA Binding E-box Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding
	Biological Process	Phosphate-containing Compound Metabolic Process Signal Transduction Inositol Phosphate Metabolic Process Phosphatidylinositol Phosphorylation Inositol Phosphate Dephosphorylation	Negative Regulation Of Transcription By RNA Polymerase II Glycogen Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Multicellular Organism Development Circadian Rhythm Hormone-mediated Signaling Pathway Proteasomal Protein Catabolic Process Negative Regulation Of Receptor Biosynthetic Process Regulation Of Lipid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Protein Destabilization Circadian Regulation Of Gene Expression Response To Lipid Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cholesterol Homeostasis Regulation Of Circadian Sleep/wake Cycle Regulation Of Circadian Rhythm Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Steroid Hormone Mediated Signaling Pathway Response To Leptin Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Circadian Temperature Homeostasis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Astrocyte Activation Positive Regulation Of Bile Acid Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Microglial Cell Activation
Pathways		Synthesis of IP2, IP, and Ins in the cytosol	NR1D1 (REV-ERBA) represses gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Circadian Clock Circadian Clock
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Lung cancer (SNP x SNP interaction) ( 24325914)	Asthma ( 31619474) Multiple sclerosis ( 31604244) White blood cell count ( 21738480)
Interacting Genes		11 interacting genes: BRCA1 C9orf16 DYNLL1 LDOC1 LIG1 MEOX2 NDC80 NECAB2 NR1D1 SYCE3 USHBP1	7 interacting genes: APP C1D INPP1 NCOR1 NCOR2 NR1D2 NR2E3
Entrez ID		3628	9572
HPRD ID		00923	03873
Ensembl ID		ENSG00000151689	ENSG00000126368
Uniprot IDs		P49441 Q6IBG4	F1D8S3 P20393
PDB IDs			1A6Y 1EF6 1GA5 1HLZ 3N00
Enriched GO Terms of Interacting Partners?
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