IL13RA2 and IL4

Number of citations of the paper that reports this interaction (PubMedID 9130652)
16

Data Source:
HPRD (in vivo, in vitro)

		IL13RA2	IL4
Description		interleukin 13 receptor subunit alpha 2	interleukin 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Receptor Activity Protein Binding Cytokine Binding	Cytokine Activity Interleukin-4 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Negative Regulation Of Immunoglobulin Production Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Negative Regulation Of Mast Cell Degranulation	Immune Response Cholesterol Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Macroautophagy Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interleukin-13 Production T-helper 2 Cell Cytokine Production Type 2 Immune Response Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Activation Of Janus Kinase Activity Myeloid Dendritic Cell Differentiation Negative Regulation Of Apoptotic Process Connective Tissue Growth Factor Biosynthetic Process Regulation Of Isotype Switching Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Dendritic Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Cellular Respiration Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of ATP Biosynthetic Process
Pathways		Interleukin-4 and Interleukin-13 signaling	Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling
Drugs		AER001
Diseases			Asthma
GWAS			Asthma ( 31619474 29273806) Asthma (childhood onset) ( 31036433 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825) Atopic march ( 26542096) Inflammatory bowel disease ( 23128233) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624)
Interacting Genes		15 interacting genes: AKT1 BAG4 BRMS1 CASP8 EGFR ERBB2 ESR2 IGF1R IL13 IL4 NOTCH2 PALB2 PAX2 PIK3CA RB1CC1	7 interacting genes: A2M CD53 FBXO7 IL13RA2 IL2RG IL4R PIK3CD
Entrez ID		3598	3565
HPRD ID		02132	00989
Ensembl ID		ENSG00000123496	ENSG00000113520
Uniprot IDs		Q14627	D4HNR6 P05112 Q5FC01
PDB IDs		3LB6	1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX 6OEL
Enriched GO Terms of Interacting Partners?
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