IL1RAP and IL1A

Number of citations of the paper that reports this interaction (PubMedID 9820540)
29

Data Source:
HPRD (in vitro)

		IL1RAP	IL1A
Description		interleukin 1 receptor accessory protein	interleukin 1 alpha
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane Glutamatergic Synapse	Extracellular Region Extracellular Space Cytosol
	Molecular Function	Interleukin-33 Receptor Activity Interleukin-1 Receptor Activity Interleukin-1 Receptor Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Cytokine Activity Interleukin-1 Receptor Binding Copper Ion Binding Protein Binding
	Biological Process	Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-5 Production Interleukin-33-mediated Signaling Pathway Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synapse Assembly Protein-containing Complex Assembly Interleukin-1-mediated Signaling Pathway Interleukin-4 Secretion Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly Positive Regulation Of Interleukin-6 Secretion	Fever Generation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Inflammatory Response To Antigenic Stimulus Apoptotic Process Inflammatory Response Negative Regulation Of Cell Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Response To Heat Ectopic Germ Cell Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Response To Copper Ion Positive Regulation Of Protein Secretion Positive Regulation Of Cytokine Secretion Positive Regulation Of Cell Division Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Interleukin-2 Secretion Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Interleukin-6 Secretion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Senescence-Associated Secretory Phenotype (SASP) Interleukin-1 processing Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection
Drugs			Rilonacept
Diseases			Graft-versus-host disease
GWAS		Blood protein levels ( 30072576 29875488 28240269) Longitudinal change in brain amyloid plaque burden ( 26268530) Lung cancer ( 18385676) Waist circumference ( 20966902)	Dysmenorrheic pain severity ( 29855537) Endometriosis ( 20844546 28537267) Gestational age at birth (child effect) ( 31477735) Interleukin-1-receptor antagonist levels ( 22205395) Post-term birth ( 31477735) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
Interacting Genes		21 interacting genes: AP2M1 CCNI IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCHF8 MC4R MYD88 PIK3R1 PRKCI PRPF40A PTPRD RAC1 SIRPA STAT3 TICAM2 TOLLIP	11 interacting genes: CAPN1 CASP1 HAX1 IL1R1 IL1R2 IL1RAP KPNA6 MEOX2 NDN NFKBIE S100A13
Entrez ID		3556	3552
HPRD ID		04021	00988
Ensembl ID		ENSG00000196083	ENSG00000115008
Uniprot IDs		A8K6K4 Q9NPH3	P01583
PDB IDs		3O4O 4DEP	1ITA 2ILA 2KKI 2L5X 5UC6
Enriched GO Terms of Interacting Partners?
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