IL1R1 and IL1F10

Number of citations of the paper that reports this interaction (PubMedID 11278614)
37

Data Source:
HPRD (in vitro)

		IL1R1	IL1F10
Description		interleukin 1 receptor type 1	interleukin 1 family member 10
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane	Extracellular Region Extracellular Space
	Molecular Function	Protease Binding Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Interleukin-1 Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Cytokine Activity Interleukin-1 Receptor Binding
	Biological Process	Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Positive Regulation Of Neutrophil Extravasation Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Interleukin-1-mediated Signaling Pathway	Inflammatory Response To Antigenic Stimulus Inflammatory Response Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus
Pathways		Interleukin-10 signaling Interleukin-1 signaling	Interleukin-38 signaling Interleukin-36 pathway
Drugs		Anakinra SD118 OMS-103HP
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29785011) Ankylosing spondylitis ( 23749187) Asthma ( 30929738 31619474 29785011 22561531) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Blood protein levels ( 30072576 28240269) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 26394269) Serum protein levels (sST2) ( 23999434) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	C-reactive protein ( 22939635) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Coronary artery disease ( 29212778) Dysmenorrheic pain ( 27454463) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Inflammatory biomarkers ( 24182552) Interleukin-1-receptor antagonist levels ( 22205395) Stroke ( 26089329) Total cholesterol levels ( 29083408)
Interacting Genes		12 interacting genes: HYOU1 IL1A IL1B IL1F10 IL1RAP IL1RN IRAK2 MYD88 PIK3R1 SIGIRR TICAM2 TOLLIP	1 interacting genes: IL1R1
Entrez ID		3554	84639
HPRD ID		00994	17144
Ensembl ID		ENSG00000115594	ENSG00000136697
Uniprot IDs		B8ZZW4 P14778	Q8WWZ1
PDB IDs		1G0Y 1IRA 1ITB 4DEP 4GAF	5BOW
Enriched GO Terms of Interacting Partners?
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