FAS and TNFSF13

Number of citations of the paper that reports this interaction (PubMedID 10706119)
26

Data Source:
HPRD (in vitro)

		FAS	TNFSF13
Description		Fas cell surface death receptor	TNF superfamily member 13
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Body Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Extracellular Exosome	Extracellular Region Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Calmodulin Binding Kinase Binding Signaling Receptor Activity Identical Protein Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Immune Response Signal Transduction Regulation Of Stress-activated MAPK Cascade Cellular Response To Amino Acid Starvation Fas Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Protein-containing Complex Assembly Cellular Response To Mechanical Stimulus Cellular Response To Hyperoxia Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Immune Response Signal Transduction Positive Regulation Of Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of MRNA Stability Positive Regulation Of Isotype Switching To IgA Isotypes
Pathways		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 FasL/ CD95L signaling	HuR (ELAVL1) binds and stabilizes mRNA TNFs bind their physiological receptors
Drugs
Diseases		Hodgkin lymphoma Esophageal cancer Chronic lymphocytic leukemia (CLL) Adult T-cell leukemia
GWAS		Ankylosing spondylitis ( 30946743) Atrioventricular conduction ( 21041692) Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Chronic lymphocytic leukemia ( 28165464 26956414 24292274 23770605) Immunoglobulin A ( 20694011) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) Selective IgA deficiency ( 27723758)	Albumin-globulin ratio ( 29403010) Bitter alcoholic beverage consumption ( 31046077) Chin dimples ( 27182965) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) IgA levels ( 22864923 28628107) IgA nephropathy ( 26028593 25305756 22197929) IgM levels ( 23118916) Myopia ( 27182965) Non-albumin protein levels ( 22558069 29403010) Serum total protein level ( 29403010) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		49 interacting genes: ANK3 APAF1 APOA5 ATP6V0B BAG6 BTK CALM1 CASP8 CASP8AP2 CCND3 CD47 CRMP1 DAXX DNAJC5 EEF1A1 EGFR ERG28 EZR FADD FAF1 FAF2 FAIM2 FASLG FBF1 FEM1B FYN GADD45A HIPK3 HNRNPC KRIT1 LCK LRIF1 MBD4 MET PDCD6 PRKCA PTPN13 PTPN6 RAP1A RIPK1 SUMO1 TCAP TMX1 TNFSF13 TRADD TRAF3 UBA7 UBE2I UBQLN1	12 interacting genes: CAMK1D FAS FURIN KRAS PIK3CA SDC2 TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF1A TNFSF13B
Entrez ID		355	8741
HPRD ID		00609	05128
Ensembl ID		ENSG00000026103	ENSG00000161955
Uniprot IDs		K9J972 P25445 Q59FU8	B3KR02 O75888 Q2QBA2
PDB IDs		1BZI 1DDF 2NA7 3EWT 3EZQ 3THM 3TJE	4ZCH
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?