POLN and ATR

Number of citations of the paper that reports this interaction (PubMedID 21242293)
41

Data Source:
BioGRID (enzymatic study)

		POLN	ATR
Description		DNA polymerase nu	ATR serine/threonine kinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Golgi Apparatus PML Body
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Cyclin Binding	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MutLalpha Complex Binding MutSalpha Complex Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA-dependent DNA Replication Translesion Synthesis Interstrand Cross-link Repair	DNA Damage Checkpoint Telomere Maintenance DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Multicellular Organism Development Negative Regulation Of DNA Replication Peptidyl-serine Phosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase Cellular Response To UV Interstrand Cross-link Repair Response To Drug Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Protein Localization To Chromosome, Telomeric Region Cellular Response To Gamma Radiation Replicative Senescence Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Cellular Response To Heat Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Pathways		Fanconi Anemia Pathway	Meiotic synapsis Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases			Alveolar rhabdomyosarcoma Seckel syndrome
GWAS		Alzheimer's disease ( 22159054) Diastolic blood pressure ( 30224653) Diffusing capacity of carbon monoxide ( 30694715) Height ( 31562340)	Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Red blood cell count ( 29403010 27863252) Red cell distribution width ( 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		2 interacting genes: ATR POLDIP2	50 interacting genes: AATF ABL1 AP1B1 AP3B1 ARHGEF1 ATM BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CHUK CLSPN CREB1 DCAF1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 ETV1 FANCA FANCD2 FANCI FLT1 H2AX KDR LIG4 MCM2 MCPH1 MRE11 MSH2 NBN PA2G4 PIK3CA POLD1 POLN PPP2R3A RAD17 RASSF1 RHEB TP53 TREX1 UPF1 XPA XRCC5
Entrez ID		353497	545
HPRD ID		17876	08369
Ensembl ID		ENSG00000130997	ENSG00000175054
Uniprot IDs		Q7Z5Q5	Q13535
PDB IDs		4XVI 4XVK 4XVL 4XVM	5YZ0
Enriched GO Terms of Interacting Partners?
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