TICAM2 and TLR4

  • Number of citations of the paper that reports this interaction (PubMedID 14517278)
  • 318
  • Data Source:
  • HPRD (two hybrid, in vivo, in vitro)

TICAM2

TLR4

Description toll like receptor adaptor molecule 2 toll like receptor 4
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Allergic disease (asthma, hay fever or eczema) ( 29679657)
  • Response to antidepressants (symptom improvement) ( 29160301)
  • Blood protein levels ( 29875488 28240269)
  • BMI (adjusted for smoking behaviour) ( 28443625)
  • BMI in non-smokers ( 28443625)
  • Body mass index ( 25673413 28448500)
  • Body mass index (joint analysis main effects and physical activity interaction) ( 28448500)
  • Body mass index (joint analysis main effects and smoking interaction) ( 28443625)
  • Body mass index in physically active individuals ( 28448500)
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Cognitive decline rate in late mild cognitive impairment ( 26252872)
  • Experiencing mood swings ( 29500382)
  • Feeling fed-up ( 29500382)
  • Feeling guilty ( 29500382)
  • Impulsivity (motor) ( 30718321)
  • Irritable mood ( 29500382)
  • Metabolite levels ( 23823483)
  • Neurociticism ( 29500382)
  • Neuroticism ( 29255261)
  • Obesity-related traits ( 23251661)
  • Osteoarthritis biomarkers ( 25057126)
  • Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311)
  • Prostate-specific antigen levels ( 28139693)
  • Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)
Interacting Genes 18 interacting genes: FTH1 IL1R1 IL1RAP IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 MEOX2 OPN1LW PIAS2 SARM1 TICAM1 TIRAP TLR3 TLR4 TRAF6 26 interacting genes: BCL10 BTK CD14 CNPY4 DEFB4A HMGB1 HSP90B1 IRAK1 IRAK2 LY96 MAPK8IP3 MYD88 NOX4 RAB14 RIPK2 RNF216 SERTAD1 SIGIRR SMAD3 SYK TICAM2 TIRAP TLR1 TLR5 TOLLIP UBQLN1
Entrez ID 353376 7099
HPRD ID 16313 04325
Ensembl ID ENSG00000243414 ENSG00000136869
Uniprot IDs Q86XR7 O00206
PDB IDs 2M1W 2Z62 2Z63 2Z65 2Z66 3FXI 3UL7 3UL8 3UL9 3ULA 4G8A 5NAM 5NAO
Enriched GO Terms of Interacting Partners?
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