RBPJ and NCOR2

Number of citations of the paper that reports this interaction (PubMedID 11509665)
38

Data Source:
HPRD (in vivo, two hybrid)

		RBPJ	NCOR2
Description		recombination signal binding protein for immunoglobulin kappa J region	nuclear receptor corepressor 2
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GO Annotations	Cellular Component	Nuclear Chromatin MAML1-RBP-Jkappa- ICN1 Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Transcriptional Repressor Complex	Histone Deacetylase Complex Nuclear Chromatin Nucleus Nucleoplasm Membrane Nuclear Matrix Nuclear Body Transcriptional Repressor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Repressing Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein N-terminus Binding Repressing Transcription Factor Binding	RNA Polymerase II Regulatory Region DNA Binding Chromatin Binding Transcription Corepressor Activity Notch Binding Protein Binding Nuclear Hormone Receptor Binding Glucocorticoid Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein-containing Complex Binding Retinoid X Receptor Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Somitogenesis Epithelial To Mesenchymal Transition Blood Vessel Remodeling Inflammatory Response To Antigenic Stimulus Secondary Heart Field Specification Outflow Tract Morphogenesis Endocardium Morphogenesis Aortic Valve Development Pulmonary Valve Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cardiac Left Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Humoral Immune Response Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Negative Regulation Of Cell Proliferation Auditory Receptor Cell Fate Commitment Epidermal Cell Fate Specification Positive Regulation Of Gene Expression Pituitary Gland Development B Cell Differentiation Keratinocyte Differentiation Negative Regulation Of Ossification Positive Regulation Of BMP Signaling Pathway Somatic Stem Cell Population Maintenance Dorsal Aorta Morphogenesis Atrioventricular Canal Development Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Timing Of Cell Differentiation Sebaceous Gland Development Hair Follicle Maturation Positive Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Clara Cell Differentiation Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Fate Commitment Notch Signaling Involved In Heart Development Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Blood Vessel Lumenization Interleukin-4 Secretion Blood Vessel Endothelial Cell Fate Specification Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Ephrin Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Lactation Response To Organonitrogen Compound Regulation Of Cellular Ketone Metabolic Process Regulation Of Lipid Metabolic Process Response To Estradiol Estrous Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription	PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Rheumatoid arthritis ( 24449572 23143596 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065) Clubfoot ( 24667120) Cocaine dependence ( 23958962) Cognitive performance ( 19734545) Diastolic blood pressure ( 30224653) Height ( 31562340) Lung function (FEV1) ( 30061609) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		28 interacting genes: APP CCNF CIR1 FHL1 GADD45A GSK3B HDAC1 HMGB1 HSPB1 KAT2A KAT2B MAML1 MED27 NCOR1 NCOR2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PTF1A RPS6KA6 SIN3A SND1 SNW1 SPEN SPOP SUFU TP53	88 interacting genes: AHR AKT1 AP2M1 AR ARNT ATXN1 ATXN1L BCL6 C1D CBFA2T2 CDK2 CEBPB CEP63 CHUK CIR1 CNOT2 DDX20 E2F1 ESR1 ESR2 FOS FOXP1 H4C1 HDAC1 HDAC10 HDAC3 HDAC4 HDAC5 HDAC7 HNF4A INPP5K IRF5 JUN KLF5 MYBL2 MYOD1 NCOA3 NCOA6 NCOR1 NFE2L2 NFKB1 NFKBIA NFKBIB NFKBIE NR1D1 NR1H2 NR1H4 NR1I2 NR2F1 NR2F2 NR3C1 NR4A1 PIN1 PML POU2F1 PPARA PPARD PPARG RANBP9 RARA RARB RARG RBPJ RELA RUNX1 RUNX1T1 RXRA RXRG SAP30 SIN3A SKIL SNW1 SP1 SPEN SRF STAT5A STAT5B SUMO1 TBL1X THRA THRB TNIK TNIP2 UBE2I VDR YWHAE ZBTB16 ZBTB7A
Entrez ID		3516	9612
HPRD ID		00920	02910
Ensembl ID		ENSG00000168214	ENSG00000196498
Uniprot IDs		Q06330	C9J0Q5 C9JE98 Q9Y618
PDB IDs		2F8X 3NBN 3V79 6PY8	1KKQ 1R2B 1XC5 2GPV 2L5G 2LTP 2ODD 2RT5 3R29 3R2A 4A69 4OAR 5X8Q 5X8X 5ZOO 5ZOP 6A22 6IVX
Enriched GO Terms of Interacting Partners?
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