IGHG1 and TRIM21

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, x-ray crystallography, pull down)

		IGHG1	TRIM21
Description		immunoglobulin heavy constant gamma 1 (G1m marker)	tripartite motif containing 21
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane Immunoglobulin Complex, Circulating Extracellular Exosome Blood Microparticle	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol SCF Ubiquitin Ligase Complex Cytoplasmic Vesicle Ribonucleoprotein Complex
	Molecular Function	Antigen Binding Protein Binding Immunoglobulin Receptor Binding	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	Phagocytosis, Recognition Phagocytosis, Engulfment Complement Activation Complement Activation, Classical Pathway Cytokine-mediated Signaling Pathway Regulation Of Complement Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Defense Response To Bacterium Innate Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation	Protein Polyubiquitination Protein Monoubiquitination Cell Cycle Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Response To Interferon-gamma Innate Immune Response Positive Regulation Of Cell Cycle Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Protein Deubiquitination Negative Regulation Of Viral Release From Host Cell
Pathways			STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Composite immunoglobulin trait (IgG/IgM) ( 28628107) IgG levels ( 23225573)	Lung cancer ( 28604730)
Interacting Genes		7 interacting genes: CD40LG FCGR3A FCGR3B IGKC SWAP70 TRIM21 UCHL5	52 interacting genes: APC CALR CASP8AP2 CDC34 CUL1 DAXX DCP2 DZIP3 FADD FBXW11 GABARAP GABARAPL1 GABARAPL2 GRAP HLA-DRB1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NIF3L1 PFKP RBCK1 RNF111 RO60 SKP2 SQSTM1 TBK1 TRIM27 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2E1 UBE2H UBE2I UBE2L3 UBE2N UBE2V2 UBE2W USP15 USP2 USP4 YWHAZ
Entrez ID		3500	6737
HPRD ID		11755	00170
Ensembl ID		ENSG00000211896	ENSG00000132109
Uniprot IDs			P19474
PDB IDs			2IWG 5JPX 5OLM 6FGA 6S53
Enriched GO Terms of Interacting Partners?
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