IGFBP6 and DDX10

		IGFBP6	DDX10
Description		insulin like growth factor binding protein 6	DEAD-box helicase 10
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Insulin-like Growth Factor Binary Complex	Nucleus
	Molecular Function	Fibronectin Binding Signaling Receptor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	RNA Binding RNA Helicase Activity ATP Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway	RRNA Processing Anterior Head Development
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)	Knee osteoarthritis ( 28916551) Systolic blood pressure ( 27841878)
Interacting Genes		5 interacting genes: DDX10 IGF1 IGF2 TF UBQLN4	16 interacting genes: ANTXR2 APP ARHGAP20 ARL2BP BCO2 CUL5 DES DSC3 FBXO7 HSPB2 IGFBP6 NPAT PGR PTS SIRPA SLN
Entrez ID		3489	1662
HPRD ID		00902	03138
Ensembl ID		ENSG00000167779	ENSG00000178105
Uniprot IDs		P24592	Q13206
PDB IDs		1RMJ	2PL3
Enriched GO Terms of Interacting Partners?
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