IGF2 and NMRK2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		IGF2	NMRK2
Description		insulin like growth factor 2	nicotinamide riboside kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen	Nucleoplasm Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity	Protein Binding ATP Binding Kinase Activity Metal Ion Binding Ribosylnicotinamide Kinase Activity Ribosylnicotinate Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation In Utero Embryonic Development Embryonic Placenta Development Positive Regulation Of Protein Phosphorylation Platelet Degranulation Glucose Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription, DNA-templated Multicellular Organism Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Exocrine Pancreas Development Regulation Of Histone Modification Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Cellular Protein Metabolic Process Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Striated Muscle Cell Differentiation Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Embryonic Placenta Morphogenesis Spongiotrophoblast Cell Proliferation Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Glycogen (starch) Synthase Activity	NAD Biosynthetic Process Phosphorylation NAD Metabolic Process Negative Regulation Of Myoblast Differentiation
Pathways		Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Nicotinate metabolism
Drugs
Diseases		Beckwith-Wiedemann syndrome Russell-Silver syndrome; Silver-Russell syndrome Adrenal carcinoma
GWAS		Birth weight ( 27680694) Celiac disease ( 23936387) Creatinine levels ( 29403010) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 31015462 30604766) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Glomerular filtration rate ( 29403010) Length of menstrual cycle ( 30202859) Prostate cancer ( 19767753) Pursuit maintenance gain ( 29064472) Type 2 diabetes ( 30297969 30718926) Urate levels ( 31578528)
Interacting Genes		22 interacting genes: BAG6 CCN3 CCN5 FAF1 GPC3 IDE IGF1R IGF2R IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 INSR NMRK2 PCSK4 PLG RBPMS TF VTN	6 interacting genes: APP CDKN1A IGF2 ITGB1 LRP12 SAT1
Entrez ID		3481	27231
HPRD ID		00939	16371
Ensembl ID		ENSG00000167244	ENSG00000077009
Uniprot IDs		E3UN46 P01344	Q9NPI5
PDB IDs		1GF2 1IGL 2L29 2V5P 3E4Z 3KR3 5L3L 5L3M 5L3N
Enriched GO Terms of Interacting Partners?
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