ID3 and PAX5

Number of citations of the paper that reports this interaction (PubMedID 12054881)
29

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		ID3	PAX5
Description		inhibitor of DNA binding 3, HLH protein	paired box 5
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GO Annotations	Cellular Component	Nucleus	Nuclear Chromatin Fibrillar Center Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Dimerization Activity Transcription Regulator Activity Leptomycin B Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Regulation Of DNA Replication Multicellular Organism Development Central Nervous System Development Heart Development Muscle Organ Development Response To Wounding Positive Regulation Of Gene Expression Cell Differentiation Epithelial Cell Differentiation Notochord Development Circadian Regulation Of Gene Expression Odontogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Cellular Response To Leptomycin B Positive Regulation Of Nucleic Acid-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Humoral Immune Response Multicellular Organism Development Spermatogenesis Aging Animal Organ Morphogenesis Lateral Ventricle Development Cerebral Cortex Development Adult Behavior Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Histone H3-K9 Methylation
Pathways		NGF-stimulated transcription	RUNX1 regulates transcription of genes involved in BCR signaling
Drugs
Diseases			Lymphoplasmacytic lymphoma
GWAS			Alzheimer's disease ( 30636644) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Coronary artery disease in type 1 diabetes ( 29695241) HIV-1 susceptibility ( 25786224) Intelligence ( 22449649) Major depressive disorder ( 27479909) Moderate to vigorous physical activity levels ( 29899525) Morning person ( 30696823) Obesity-related traits ( 22013104)
Interacting Genes		37 interacting genes: ADD1 ATF3 CBFA2T2 CDK2 CEP350 CNOT3 CSK E2F4 ELK1 ELK4 FAM74A1 FHL2 GATA4 GNB2 GTF2A1L HES1 ID4 IFI16 IKBKG MLX MYF5 MYF6 MYOD1 MYOG PAX5 PRDM14 PUF60 RND1 RUNX1T1 SAP30 SREBF1 TCF12 TCF3 TCF4 ZNF3 ZNF408 ZNF626	16 interacting genes: CREBBP DAXX EBF1 EP300 ETS1 ID2 ID3 KPNA1 KPNA2 MAPK1 MYB RB1 RUNX1 TBP TLE4 UBE3A
Entrez ID		3399	5079
HPRD ID		02608	01334
Ensembl ID		ENSG00000117318	ENSG00000196092
Uniprot IDs		Q02535	C0KTE5 C0KTF5 E7EQT0 E7ERK2 E7ERW5 E7ES87 Q02548
PDB IDs		2LFH	1K78 1MDM
Enriched GO Terms of Interacting Partners?
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