IARS1 and EPRS1

Number of citations of the paper that reports this interaction (PubMedID 9556618)
22

Data Source:
HPRD (two hybrid, in vitro)

		IARS1	EPRS1
Description		isoleucyl-tRNA synthetase 1	glutamyl-prolyl-tRNA synthetase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex GAIT Complex Ribonucleoprotein Complex
	Molecular Function	TRNA Binding Aminoacyl-tRNA Editing Activity Isoleucine-tRNA Ligase Activity Protein Binding ATP Binding GTPase Binding	Glutamate-tRNA Ligase Activity Proline-tRNA Ligase Activity Protein Binding ATP Binding Zinc Ion Binding RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity GTPase Binding
	Biological Process	Osteoblast Differentiation TRNA Aminoacylation For Protein Translation Isoleucyl-tRNA Aminoacylation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity	TRNA Aminoacylation For Protein Translation Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Negative Regulation Of Translation Cellular Response To Insulin Stimulus Protein-containing Complex Assembly Cellular Response To Interferon-gamma Regulation Of Long-chain Fatty Acid Import Into Cell
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation	Selenoamino acid metabolism Cytosolic tRNA aminoacylation tRNA modification in the nucleus and cytosol
Drugs		L-Isoleucine	Glutamic Acid L-Proline '5'-O-(N-(L-Prolyl)-Sulfamoyl)Adenosine 5'-O-(N-(L-Cysteinyl)-Sulfamoyl)Adenosine '5'-O-(N-(L-Alanyl)-Sulfamoyl)Adenosine
Diseases
GWAS
Interacting Genes		6 interacting genes: APP AR EPRS1 ERBB2 GARS1 SNCA	12 interacting genes: AIMP2 ARL4D DUS2 EEF1D ESR1 HSP90AA1 IARS1 NEDD4 NELFCD RARS1 SYNCRIP TAB1
Entrez ID		3376	2058
HPRD ID		02832	00703
Ensembl ID		ENSG00000196305	ENSG00000136628
Uniprot IDs		P41252 Q6P0M4 Q7L4K8	P07814
PDB IDs			1FYJ 4HVC 4K86 4K87 4K88 5A1N 5A34 5A5H 5BMU 5V58 5VAD 5Y6L 6IY6
Enriched GO Terms of Interacting Partners?
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