HSPA8 and CITED1

Number of citations of the paper that reports this interaction (PubMedID 10722728)
31

Data Source:
BioGRID (genetic interference)
HPRD (in vivo, in vitro)

		HSPA8	CITED1
Description		heat shock protein family A (Hsp70) member 8	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
Image			No pdb structure
GO Annotations	Cellular Component	Prp19 Complex Extracellular Region Extracellular Space Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Lysosome Lysosomal Membrane Late Endosome Autophagosome Cytosol Plasma Membrane Focal Adhesion Membrane Axon Dendrite Secretory Granule Lumen Melanosome Terminal Bouton Lysosomal Lumen Perinuclear Region Of Cytoplasm Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Extracellular Exosome Blood Microparticle Lumenal Side Of Lysosomal Membrane Photoreceptor Ribbon Synapse Glycinergic Synapse Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol Postsynaptic Specialization Membrane Chaperone Complex Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	G Protein-coupled Receptor Binding Phosphatidylserine Binding RNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding MHC Class II Protein Complex Binding Protein Binding, Bridging Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Protein Binding Involved In Protein Folding Cadherin Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding C3HC4-type RING Finger Domain Binding Clathrin-uncoating ATPase Activity	Chromatin Binding Transcription Coactivator Activity Protein Binding Protein C-terminus Binding Protein Homodimerization Activity LBD Domain Binding Co-SMAD Binding
	Biological Process	MRNA Splicing, Via Spliceosome Protein Folding Response To Unfolded Protein Neurotransmitter Secretion Axo-dendritic Transport Cellular Response To Starvation Viral Process Vesicle-mediated Transport Cytokine-mediated Signaling Pathway Regulation Of Protein Stability Cellular Response To Unfolded Protein Protein Refolding Regulation Of Protein Complex Assembly Neutrophil Degranulation Regulation Of MRNA Stability Positive Regulation By Host Of Viral Genome Replication Negative Regulation Of Transcription, DNA-templated ATP Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Chaperone Cofactor-dependent Protein Refolding Regulation Of Cell Cycle Membrane Organization Regulation Of Protein Complex Stability Chaperone-mediated Autophagy Late Endosomal Microautophagy Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chaperone-mediated Protein Transport Involved In Chaperone-mediated Autophagy Clathrin Coat Disassembly Regulation Of Postsynapse Organization Regulation Of Cellular Response To Heat Negative Regulation Of Supramolecular Fiber Organization Regulation Of Protein Import Chaperone-mediated Autophagy Translocation Complex Disassembly Slow Axonal Transport	Embryonic Axis Specification Vasculogenesis Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Placenta Development Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Transcription By RNA Polymerase II Nucleocytoplasmic Transport Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Brain Development Positive Regulation Of Gene Expression Negative Regulation Of Wnt Signaling Pathway Melanocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Lipopolysaccharide Response To Insulin Response To Cytokine Response To Interferon-gamma Melanin Biosynthetic Process Regulation Of Apoptotic Process Pigmentation Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Response To CAMP Mesenchymal To Epithelial Transition SMAD Protein Signal Transduction Labyrinthine Layer Development Spongiotrophoblast Layer Development Response To Interleukin-1 Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-6 Response To Interleukin-9 Response To Interleukin-11 Response To Parathyroid Hormone Response To Transforming Growth Factor Beta Positive Regulation Of Mesenchymal Stem Cell Proliferation
Pathways		Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis CHL1 interactions AUF1 (hnRNP D0) binds and destabilizes mRNA Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation mRNA Splicing - Major Pathway Clathrin-mediated endocytosis Protein methylation GABA synthesis, release, reuptake and degradation Lipophagy Chaperone Mediated Autophagy Late endosomal microautophagy	Activation of the TFAP2 (AP-2) family of transcription factors Estrogen-dependent gene expression
Drugs		Dasatinib (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Copper Artenimol
Diseases
GWAS		Mean corpuscular hemoglobin concentration ( 29403010) Postoperative acute renal failure after cardiac surgery ( 30678657)	Chloride levels ( 29403010) Sodium levels ( 29403010)
Interacting Genes		90 interacting genes: ABI1 AIPL1 ALDOB APOB ATM BAG1 BAG2 BAG3 BAG4 BAG6 BRCA1 CAPZA1 CAPZB CCT3 CD40 CDKN2A CITED1 CLTA COL7A1 CXCR4 CYCS DNAJA1 DNAJA3 DNAJB1 DPP3 DYNLL1 EGFR ERH ESR1 FANCC FBP1 GAK GCH1 GOT2 H3C1 HDAC10 HDAC3 HGS HLTF HSF1 HSP90AA1 HSPA1A HSPBP1 HSPH1 HTN3 HTT IL32 INS JAK2 JUN LALBA MAPK8 MAPT METTL21A NMI NOA1 PHC1 PPID PTEN PTPRF RAF1 RB1 REL RGS2 SGTA SIRPA SNCA SP1 SRRT ST13 STAT1 STIP1 STMN1 STUB1 SUMO2 SUMO4 TADA3 TCERG1 TGM2 TM4SF1 TNFRSF1A TP53 TRIM38 TSSK6 TTC1 UBC UCHL1 VHL YWHAG YWHAQ	8 interacting genes: CREBBP EP300 ESR1 HSPA8 LNX1 SMAD4 TFAP2B TFAP2C
Entrez ID		3312	4435
HPRD ID		07205	02146
Ensembl ID		ENSG00000109971	ENSG00000125931
Uniprot IDs		P11142 Q53HF2 V9HW22	Q99966
PDB IDs		3AGY 3AGZ 3ESK 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 4H5N 4H5R 4H5T 4H5V 4H5W 4HWI 4KBQ 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV 6B1I 6B1M 6B1N
Enriched GO Terms of Interacting Partners?
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