HPR and IGHM

Number of citations of the paper that reports this interaction (PubMedID 10085035)
46

Data Source:
HPRD (in vitro)

		HPR	IGHM
Description		haptoglobin-related protein	immunoglobulin heavy constant mu
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Spherical High-density Lipoprotein Particle Extracellular Exosome Blood Microparticle	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Immunoglobulin Complex, Circulating Extracellular Exosome Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Hemoglobin Binding	Single-stranded DNA Binding Antigen Binding Protein Binding Phosphatidylcholine Binding Immunoglobulin Receptor Binding Peptidoglycan Binding
	Biological Process	Acute Inflammatory Response Proteolysis Receptor-mediated Endocytosis Response To Organic Substance Positive Regulation Of Cell Death	Adaptive Immune Response Phagocytosis, Recognition Phagocytosis, Engulfment Complement Activation, Classical Pathway Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation Leukocyte Migration
Pathways		Scavenging of heme from plasma
Drugs		Zinc Copper
Diseases
GWAS		Blood protein levels ( 28240269) Cholesterol, total ( 24097068 28270201 25961943 20686565 26582766) LDL cholesterol ( 24097068 25961943 20686565 26582766) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolite levels ( 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		3 interacting genes: APOA1 IGHM VKORC1	19 interacting genes: APP CD22 CD79A CEP72 GADD45A GSK3B HPR HSPA5 JCHAIN MAP3K20 MAPKAPK3 PTK2 SH3GL2 SMN1 TK1 UBQLN4 UFD1 VPREB1 VPREB3
Entrez ID		3250	3507
HPRD ID		00773	00912
Ensembl ID		ENSG00000261701	ENSG00000211899
Uniprot IDs		P00739
PDB IDs
Enriched GO Terms of Interacting Partners?
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