APBB2 and APLP2

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		APBB2	APLP2
Description		amyloid beta precursor protein binding family B member 2	amyloid beta precursor like protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Membrane Lamellipodium Growth Cone Synapse	Nucleus Endoplasmic Reticulum Lumen Plasma Membrane Membrane Integral Component Of Membrane Platelet Alpha Granule Membrane Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Protein Binding Transcription Factor Binding	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Identical Protein Binding Transition Metal Ion Binding
	Biological Process	Neuron Migration Regulation Of Transcription, DNA-templated Cell Cycle Arrest Axon Guidance Extracellular Matrix Organization Negative Regulation Of Cell Growth Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process	Platelet Degranulation G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs			Zinc
Diseases
GWAS		Dental caries ( 23259602) Glaucoma (primary open-angle) ( 31688885) Height ( 28552196) Iris color (L* coordinate) ( 29109912) Opioid sensitivity ( 24143882) Response to citalopram or escitalopram in depression ( 27622933)	Blood protein levels ( 30072576)
Interacting Genes		9 interacting genes: APLP2 APP MAPK8 NFKB1 SMAD4 SMURF1 TP53 TRADD WWOX	22 interacting genes: AKT1 APBB1 APBB2 APBB3 BRCA1 CDK1 DAB1 DAB2 DEDD ETS1 HGS HLA-A JUN JUNB KAT5 MAPK8 PIK3CA PRKCA PRNP RPL26 VKORC1 ZNF512B
Entrez ID		323	334
HPRD ID		04088	00103
Ensembl ID		ENSG00000163697	ENSG00000084234
Uniprot IDs		B4DJ88 B4E2F2 G5E9Y1 Q5I0G1 Q92870	A0A140VJE9 B4E3I5 Q06481
PDB IDs			5JBT 5TPT
Enriched GO Terms of Interacting Partners?
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Tagcloud (Intersection) ?