HMOX1 and ASL

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		HMOX1	ASL
Description		heme oxygenase 1	argininosuccinate lyase
Image
GO Annotations	Cellular Component	Extracellular Space Cell Nucleus Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Caveola Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Heme Oxygenase (decyclizing) Activity Phospholipase D Activity Structural Molecule Activity Protein Binding Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Argininosuccinate Lyase Activity Protein Binding Identical Protein Binding
	Biological Process	Angiogenesis Endothelial Cell Proliferation Wound Healing Involved In Inflammatory Response Negative Regulation Of Leukocyte Migration Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Small GTPase Mediated Signal Transduction Excretion Regulation Of Blood Pressure Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Muscle Cell Apoptotic Process Smooth Muscle Hyperplasia Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Cytokine-mediated Signaling Pathway Cellular Response To Nutrient Negative Regulation Of Mast Cell Cytokine Production Erythrocyte Homeostasis Low-density Lipoprotein Particle Clearance Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Cellular Response To Heat Response To Nicotine Intracellular Signal Transduction Heme Catabolic Process Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Mast Cell Degranulation Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Response To Estrogen Positive Regulation Of Chemokine Biosynthetic Process Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of DNA-binding Transcription Factor Activity Iron Ion Homeostasis Cellular Response To Arsenic-containing Substance Cellular Response To Cadmium Ion Cellular Response To Hypoxia Cellular Response To Cisplatin Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Liver Regeneration Positive Regulation Of Blood Vessel Diameter Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Vascular Smooth Muscle Cell Proliferation	Urea Cycle Arginine Biosynthetic Process Via Ornithine
Pathways		Heme degradation Interleukin-4 and Interleukin-13 signaling Iron uptake and transport Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Urea cycle
Drugs		NADH Formic Acid Biliverdine IX Alpha 12-Phenylheme 2-Phenylheme Verdoheme Stannsoporfin 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone	L-Arginine Argininosuccinate 2-(N-Morpholino)-Ethanesulfonic Acid
Diseases			Argininosuccinic aciduria (ARGINSA); Argininosuccinate lyase deficiency
GWAS		Hippocampal volume in mild cognitive impairment ( 29274321) Obesity-related traits ( 23251661) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		16 interacting genes: AKT1 ASL BLVRB CPSF1 CREB3 KASH5 LMNA NOS1 PDGFB POR POT1 SNF8 TERF1 TEX33 TUT1 ZNF132	9 interacting genes: CLK1 CSNK2A2 FBP1 HMOX1 MCMBP NTAQ1 OVGP1 QARS1 SRPK2
Entrez ID		3162	435
HPRD ID		00782	01948
Ensembl ID		ENSG00000100292	ENSG00000126522
Uniprot IDs		P09601 Q6FH11	A0A024RDL8 A0A0S2Z316 P04424
PDB IDs		1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM 4WD4 5BTQ 6EHA	1AOS 1K62
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?